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musculin; activated B-cell factor 1; ABF-1; class A basic helix-loop-helix protein 22; bHLHa22 (MSC, ABF1, BHLHA22)
Function:
- transcription repressor capable of inhibiting the transactivation capability of TCF3/E47
- may play a role in regulating antigen-dependent B-cell differentiation efficient DNA binding requires dimerization with another bHLH protein
- binds DNA as a homodimer or a heterodimer
- forms a heterodimer with TCF3
Structure:
- contains 1 basic helix-loop-helix (bHLH) domain
Compartment: nucleus
Expression:
- expressed in lymphoid tissues, B-cell lines & activated B-cells
General
basic helix loop helix (bHLH) family transcription factor
transcriptional silencer (transcriptional repressor)
Properties
SIZE: entity length = 206 aa
MW = 22 kD
COMPARTMENT: cell nucleus
MOTIF: glutamate-rich region {48-57}
MOTIF: glutamate residue (SEVERAL)
nuclear translocation signal {71-76}
glycine-rich region {79-91}
MOTIF: glycine-rich region {79-85}
glycine-rich region {88-91}
DNA-binding motif
SITE: 108-119
helix-loop-helix
NAME: helix-loop-helix
SITE: 120-160
FOR-BINDING-VIA: helix-loop-helix
Database Correlations
OMIM 603628
UniProt O60682
Pfam PF00010
Entrez Gene 9242
Kegg hsa:9242
References
- UniProt :accession O60682
- Entrez Gene :accession 9242