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muramidase or lysozyme
Function:
- catalyzes hydrolysis of bacterial cell walls by cleavage of N-acetylglucosamine linkages
- lysozyme in external secretions is a 1st line defense against bacterial pathogens
Structure:
- no carbohydrate
- highly basic
Compartment:
- secreted
- normal plasma constituent
- present in high concentrations in external secretions (tears, saliva, sweat)
Expression:
- synthesized by macrophages, neutrophils & monocytes
Related
lysozyme Ag in tissue
lysozyme in body fluid (serum/plasma/urine/CSF)
Specific
lysozyme-C; 1,4-beta N-acetylmuramidase C (LYZ, LZM)
General
glycosidase (glycoside hydrolase)
lysosomal hydrolase
secreted protein
other antibiotic
Properties
SIZE: MW = 14.5 kD
COMPARTMENT: lysosome
serum
exocrine secretion
MOTIF: active site
glycosylation site
Database Correlations
OMIM 153450
References
Clinical Guide to Laboratory Tests, 4th edition, HB Wu ed,
WB Saunders, Philadelphia, 2006