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multisynthetase complex
Function:
- synthesis of aminoacyl-tRNAs
- multisubunit complex that groups tRNA ligases for Arg, Asp, Glu, Gln, Ile, Leu, Lys, Met & Pro
Structure:
- consists of:
- bifunctional glutamyl-prolyl-tRNA synthetase
- monospecific
- isoleucyl tRNA synthetase
- leucyl RNA tsynthetase
- glutaminyl tRNA synthetase
- methionyl tRNA synthetase
- lysyl tRNA synthetase
- arginyl tRNA synthetase aspartyl-tRNA synthetases
- auxiliary proteins, p18, p48, p43, JTV1 (p38)
General
amino acyl tRNA synthetase
molecular complex
Properties
MOTIF: active site
SUBUNITS: alpha-globin transcription factor CP2
COMPARTMENT: cell nucleus
MOTIF: binding site
SITE: 133-395
FOR-BINDING-OF: deoxyribonucleic acid (DNA)
MOTIF: proline-rich region
SITE: 314-319
MOTIF: proline residue (SEVERAL)
glutamine-rich region {396-413}
MOTIF: glutamine residue (SEVERAL)
bifunctional aminoacyl-tRNA synthetase
MOTIF: Glutamyl-tRNA synthetase {164-759}
MOTIF: "HIGH" region {204-214}
"KMSKS" region {432-436}
ATP-binding site
NAME: ATP-binding site
SITE: 435-435
WHEP-TRS 1 {749-805}
3 X 57 AA approximate repeats {760-956}
MOTIF: WHEP-TRS 2 {822-878}
Ser phosphorylation site {S885}
Ser phosphorylation site {S886}
Ser phosphorylation site {S891}
Thr phosphorylation site {T898}
WHEP-TRS 3 {900-956}
Charged {959-991}
Ser phosphorylation site {S1000}
Prolyl-tRNA synthetase {1007-1512}
transcription factor NF-E4 (2)
COMPARTMENT: cell nucleus
References
UniProt :accession Q12800, P07814
Components
alpha-globin transcription factor CP2 (transcription factor LSF, SAA3 enhancer factor, TFCP2, LSF, SEF)
bifunctional aminoacyl-tRNA synthetase (prolyl tRNA synthetase, glutamyl tRNA synthetase, EPRS, GLNS, PARS, QARS, QPRS, PIG32)
transcription factor NF-E4 (NFE4)