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multiple tumor suppressor-2 (MTS2) gene; CDKN2B
Gene found on same cosmid as MTS1.
Related
cyclin-dependent kinase 4 inhibitor B; p14-INK4b; p15-INK4b; p15INK4B; multiple tumor suppressor 2; MTS-2 (CDKN2B, MTS2)
General
tumor suppressor gene or anti-oncogene
Properties
TEMPLATE-FOR: messenger RNA
TEMPLATE-FOR: cyclin-dependent kinase 4 inhibitor B
LOCUS: human chromosome-9 P21
MOTIF: SP1-binding site (3)
SITE: -110--30
FOR-BINDING-OF: transcription factor Sp1
transcriptional start site
exon
intron
transcriptional termination site
Database Correlations
OMIM 600431
References
- Kamb A, Gruis NA, Weaver-Feldhaus J, Liu Q,
Harshman K, Tavtigian SV, Stockert E, Day RS 3rd, Johnson BE,
Skolnick MH.
A cell cycle regulator potentially involved in genesis of many
tumor types.
Science. 1994 Apr 15;264(5157):436-40.
PMID: 8153634
- Li et al. J Biol Chem 270(45):26750-3 1995