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multigene testing; expression profile
Indications:
- assess need for chemotherapy in patients with cancer [4]
Notes:
- panels are available that screen for mutations in up to 30-70 genes [1,2]; the problem becomes how to interpret the results
- Guardant360 test
- targets 70 genes
- sensitivity & specificity of detecting advanced cancer from blood specimen is 78-86% compared with tumor biopsy, dependent upon tumor type; specificity is 98% if samples collected within 6 months of each other [2]
- CancerSEEK [3]
- targets 16 genes + 8 proteins
- machine-based learning analyzes data
Specific
CancerSEEK
Lunar-2
General
molecular diagnostic test
References
- Orciari Herman A, Fairchild DG, Di Francesco L
Multigene Testing Opening a Can of Worms
Physician's First Watch, Sept 24, 2014
David G. Fairchild, MD, MPH, Editor-in-Chief
Massachusetts Medical Society
http://www.jwatch.org
- Zill OA et al
Somatic genomic landscape of over 15,000 patients with
advanced-stage cancer from clinical next-generation sequencing
analysis of circulating tumor DNA.
J Clin Oncol 34, 2016 (suppl; abstr LBA11501)
http://abstracts.asco.org/176/AbstView_176_171265.html
- Castellino AM
CancerSEEK: Blood Test That Detects Eight Common Cancers
Medscape - Jan 18, 2018.
https://www.medscape.com/viewarticle/891491
- Cohen JD, Li L, Wang Y et al
Detection and localization of surgically resectable cancers
with a multi-analyte blood test.
Science. Jan 18, 2018
PMID: 29348365
http://science.sciencemag.org/content/early/2018/01/17/science.aar3247
- Medical Knowledge Self Assessment Program (MKSAP) 19.
American College of Physicians, Philadelphia 2021