Search
multifunctional protein ADE2; phosphoribosylaminoimidazole succinocarboxamide synthase; SAICAR synthetase; phosphoribosylaminoimidazole carboxylase (ADE2, AIRC, PAICS, PAIS)
Function:
- purine metabolism; IMP biosynthesis via de novo pathway
- 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from N(2)-formyl-N1-(5-phospho-D-ribosyl)glycinamide: step 3/5
- purine metabolism; IMP biosynthesis via de novo pathway
- 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from N(2)-formyl-N1-(5-phospho-D-ribosyl)glycinamide: step 4/5
ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate
ADP + phosphate + (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate (SAICAR)
5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate
5-amino-1-(5-phospho-D-ribosyl)imidazole + CO2
Structure:
- homooctamer
- synthetase family
- carboxylase family
Related
aminoimidazole carboxamide ribonucleotide; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (AICAR)
succinylaminoimidazole carboxamide riboside (SAICAR)
General
carboxy-lyase or decarboxylase
ligase or synthetase
multifunctional enzyme
Properties
SIZE: entity length = 425 aa
MW = 47 kD
MOTIF: SAICAR synthetase {2-260}
acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
Ser phosphorylation site {S27}
arginine residue {R101}
serine residue {S107}
Ser phosphorylation site {S107}
arginine residue {R215}
Thr phosphorylation site {T238}
Linker {261-266}
AIR carboxylase {267-425}
MOTIF: histidine residue {H303}
serine residue {S332}
glycine residue {G334}
Database Correlations
OMIM 172439
UniProt P22234
PFAM correlations
Entrez Gene 10606
Kegg hsa:1060
ENZYME correlations
References
UniProt :accession P22234