multidrug resistance-associated protein 1; ATP-binding cassette sub-family C member 1; LTC4 transporter (ABCC1, MRP, MRP1)

Function: - role in active transport of drugs into subcellular organelles - may influence drug distribution indirectly - confers resistance to anticancer drugs - transports LTC4 - may protect milk against xenobiotics (putative) Structure: - belongs to the ABC transporter family, conjugate transporter (TC 3.A.1.208) subfamily - contains 2 ABC transmembrane type-1 domains - contains 2 ABC transporter domains Compartment: membrane Alternative splicing: named isoforms=9 Additional isoforms seem to exist Expression: - lung, testis & peripheral blood mononuclear cells

General

ATP-binding cassette sub-family C (ABC transporter-C, ABCC) glycoprotein phosphoprotein transmembrane 17 protein

Properties

SIZE: entity length = 1531 aa MW = 172 kD COMPARTMENT: cellular membrane MOTIF: exoplasmic domain {1-33} MOTIF: N-glycosylation site {N19} N-glycosylation site {N23} transmembrane domain {34-54} cytoplasmic loop {55-74} transmembrane domain {75-95} exoplasmic loop {96-100} transmembrane domain {101-121} cytoplasmic loop {122-133} transmembrane domain {134-154} exoplasmic loop {155-172} transmembrane domain {173-193} cytoplasmic loop {194-316} transmembrane domain {317-337} exoplasmic loop {338-363} transmembrane domain {364-384} cytoplasmic loop {385-440} transmembrane domain {441-461} exoplasmic loop {462-464} transmembrane domain {465-485} cytoplasmic loop {486-547} transmembrane domain {548-568} exoplasmic loop {569-590} transmembrane domain {591-611} cytoplasmic loop {612-967} MOTIF: ABC transporter 1 {644-868} ATP-binding site NAME: ATP-binding site SITE: 678-685 Ser phosphorylation site {S915} transmembrane domain {968-988} exoplasmic loop {989-1025} MOTIF: N-glycosylation site {N1006} transmembrane domain {1026-1046} cytoplasmic loop {1047-1089} transmembrane domain {1090-1110} exoplasmic loop {1111-1111} transmembrane domain {1112-1132} cytoplasmic loop {1133-1203} transmembrane domain {1204-1224} exoplasmic loop {1225-1226} transmembrane domain {1227-1247} cytoplasmic domain {1248-1531} MOTIF: ABC transporter 2 {1293-1527} ATP-binding site NAME: ATP-binding site SITE: 1327-1334

Database Correlations

OMIM 158343 UniProt P33527 PFAM correlations Entrez Gene 4363