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mullerian-inhibiting factor; anti-mullerian hormone; AMH; mullerian-inhibiting substance; MIS (AMH, MIF)
Function:
- responsible for regression of mullerian ducts in males
- binds to & activates its receptor AMHR2
- able to inhibit growth of tumors derived from tissues of mullerian duct origin
- can inhibit the autophosphorylation of the EGF receptor in vitro
- does not compete with EGF for EGF receptor binding sites
Structure:
- homodimer; disulfide-linked
- belongs to the TGF-beta family
- member of superfamily of proteins that includes TGF-beta, inhibins, & activins
Compartment: secreted
Expression:
- expressed by Sertoli cells of the testis
Pathology:
- defects in AMH are the cause of persistent mullerian duct syndrome type 1
Related
anti-Mullerian hormone type-2 receptor; anti-Mullerian hormone type II receptor; AMH type II receptor; MIS type II receptor; MISRII; MRII (AMHR2, AMHR)
General
glycoprotein
oligomerizing protein
secreted protein
TGF-beta family protein
Properties
SIZE: entity length = 560 aa
MW = 59 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-18}
N-glycosylation site {N64}
N-glycosylation site {N329}
cysteine residue {C462}
MODIFICATION: cysteine residue {C526}
cysteine residue {C488}
MODIFICATION: cysteine residue {C557}
cysteine residue {C492}
MODIFICATION: cysteine residue {C559}
cysteine residue {C525}
MODIFICATION: cysteine residue {C-INTERCHAIN}
cysteine residue {C526}
MODIFICATION: cysteine residue {C462}
cysteine residue {C557}
MODIFICATION: cysteine residue {C488}
cysteine residue {C559}
MODIFICATION: cysteine residue {C492}
Database Correlations
OMIM correlations
MORBIDMAP 600957
UniProt P03971
PFAM correlations
Entrez Gene 268
Kegg hsa:268
References
- OMIM :accession 261550
- Entrez Gene :accession 268