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mucin-7; MUC-7; salivary mucin-7; apo-MG2 (MUC7, MG2)
Function:
- may function in a protective capacity by promoting the clearance of bacteria in the oral cavity & aiding in mastication, speech, & swallowing
- binds P aeruginosa pili
Structure:
- N- & O-glycosylated. contains fucose, mannose, galactose, N-acetylglucosamine & N-acetylgalactosamine
- monomer
Compartment: secreted
Expression:
- expressed in salivary gland tissues & only in those that contain mucous acinar cells (e.g. sublingual gland & submandibular gland) & not in salivary glands containing only serous acinar cells (e.g. parotid gland)
Polymorphism:
- the most common allele, MUC7*6, contains a tandem repeat domain comprising 6 repeats each composed of 23 amino acids
- these repeats are very similar but not identical
- in a large cohort of 375 individuals from a variety of ethnic backgrounds, 3 different alleles were detected, MUC7*6 being the most common, in all populations studied, followed by MUC7*5 (5 repeats), with frequency varying from 0.05 in Africans to 0.22 in East Asians
- MUC7*8 (8 repeats), a novel rare allele, was identified in 1 Northern European individual
Pathology:
- the MUC7*5 allele associated with susceptibility to asthma
General
mucin
secreted protein
Properties
SIZE: entity length = 377 aa
MW = 39 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-22}
N-glycosylation site {N97}
threonine-rich region {104-348}
MOTIF: threonine residue (SEVERAL)
N-glycosylation site {N128}
N-glycosylation site {N135}
N-glycosylation site {N146}
consensus repeat {165-187}
consensus repeat {188-210}
consensus repeat {211-233}
consensus repeat {234-256}
consensus repeat {257-279}
consensus repeat {280-302}
Database Correlations
OMIM correlations
UniProt Q8TAX7
Entrez Gene 4589
Kegg hsa:4589
References
- UniProt :accession Q8TAX7
- mucin database
http://www.medkem.gu.se/mucinbiology/databases/