mucin-5B; MUC-5B; mucin-5 subtype B, tracheobronchial; high molecular weight salivary mucin MG1; sublingual gland mucin; cervical mucin (MUC5B, MUC5)

Function: - gel-forming mucin that is thought to contribute to the lubricating & viscoelastic properties of whole saliva & cervical mucus Structure: - highly glycosylated - S-, N- & O-gylcosylated - S- mannosylated in the Cys-rich subdomains probably on the first Trp of the WXXW motif - highly O-glycosylated in the Ser/Thr-rich tandem repeat region; the repeat region is about 59% O-glycosylated with a high abundance of neuAc(2)hex(1)hexNac1-ol - the Cys in the Cys-rich subdomain repeats are not involved in disulfide bonding - contains 1 CTCK (C-terminal cystine knot-like) domain - contains 1 TIL (trypsin inhibitory-like) domain - contains 3 VWFC domains - contains 4 VWFD domains Compartment: secreted Expression: - expressed on surface airway epithelia - expressed mainly in mucous cells of submucosal glands of airway tissues - highly expressed in the sublingual gland - also found in submaxillary glands, endocervix, gall bladder, & pancreas - regulated by all-trans-retinoic acid (cell-type specific)

General

mucin secreted protein

Properties

SIZE: entity length = 5703 aa MW = 590 kD COMPARTMENT: extracellular compartment MOTIF: signal sequence {1-25} VWFD domain {76-277} MOTIF: N-glycosylation site {N145} N-glycosylation site {N201} N-glycosylation site {N254} TIL {329-386} N-glycosylation site {N402} VWFD domain {425-639} MOTIF: N-glycosylation site {N516} N-glycosylation site {N806} VWFC domain {858-918} VWFD domain {895-1100} MOTIF: N-glycosylation site {N930} N-glycosylation site {N1277} N-glycosylation site {N1293} domain {1334-4170} MOTIF: Cys-rich {1334-1433} Cys-rich {1504-1605} N-glycosylation site {N1557} N-glycosylation site {N1775} Cys-rich {1785-1886} Ser/Thr-rich {1891-2199} N-glycosylation site {N2192} Cys-rich {2314-2414} Ser/Thr-rich {2419-2728} N-glycosylation site {N2721} Cys-rich {2843-2943} Ser/Thr-rich {2948-3426} N-glycosylation site {N3419} Cys-rich {3541-3641} Ser/Thr-rich {3646-3955} N-glycosylation site {N3948} Cys-rich {4070-4170} Ser/Thr-rich {4175-4820} MOTIF: N-glycosylation site {N4745} N-glycosylation site {N4901} N-glycosylation site {N4958} N-glycosylation site {N4965} N-glycosylation site {N4987} VWFD domain {5015-5246} MOTIF: N-glycosylation site {N5037} N-glycosylation site {N5052} N-glycosylation site {N5156} VWFC domain {5353-5425} N-glycosylation site {N5427} VWFC domain {5462-5528} MOTIF: N-glycosylation site {N5467} N-glycosylation site {N5506} N-glycosylation site {N5507} N-glycosylation site {N5543} N-glycosylation site {N5553} C-terminal cystine knot {5594-5683} MOTIF: cysteine residue {C5594} MODIFICATION: cysteine residue {C5646} N-glycosylation site {N5604} N-glycosylation site {N5618} cysteine residue {C5622} MODIFICATION: cysteine residue {C5660} cysteine residue {C5626} MODIFICATION: cysteine residue {C5676} cysteine residue {C5643} MODIFICATION: cysteine residue {C5678} cysteine residue {C5645} MODIFICATION: cysteine residue {C5682} cysteine residue {C5646} MODIFICATION: cysteine residue {C5594} cysteine residue {C5660} MODIFICATION: cysteine residue {C5622} N-glycosylation site {N5662} cysteine residue {C5676} MODIFICATION: cysteine residue {C5626} cysteine residue {C5678} MODIFICATION: cysteine residue {C5643} cysteine residue {C5682} MODIFICATION: cysteine residue {C5645}

Database Correlations

OMIM 600770 UniProt Q9HC84 PFAM correlations Entrez Gene 727897 Kegg hsa:727897