MSIN3A-like histone deacetylase complex; msin3A-like corepressor complex

Function: - acts to repress transcription by deacetylation of nucleosomal histones Subunits: - SIN3A, HDAC1, HDAC2, RBBP4/RbAp48, RBBP7/RbAp46, SAP30 & ING2

General

hydrolase molecular complex

Properties

MOTIF: active site SUBUNITS: paired amphipathic helix protein sin3a COMPARTMENT: cell nucleus MOTIF: Ser phosphorylation site {S10} HCFC1 interaction {119-196} MOTIF: paired amphipathic helix {119-189} REST interaction {205-480} MOTIF: proline-rich region SITE: 218-285 MOTIF: proline residue (SEVERAL) Ser phosphorylation site {S277} Ser phosphorylation site {S289} paired amphipathic helix {300-383} paired amphipathic helix {456-525} MOTIF: SAP30 interaction {458-525} NCOR1 interaction {523-850} MOTIF: SUDS3/SAP130 interaction {524-659} HDAC1/ARID4B interaction {687-829} Ser phosphorylation site {S832} glutamate-rich region {835-841} MOTIF: glutamate residue (SEVERAL) Ser phosphorylation site {S860} OGT interaction {888-967} MOTIF: coiled coil {903-932} Ser phosphorylation site {S940} Ser phosphorylation site {S1108} Ser phosphorylation site {S1112} histone deacetylase 1 COMPARTMENT: cell nucleus MOTIF: Histone deacetylase {9-321} MOTIF: histidine residue {H141} Tyr phosphorylation site {Y221} Ser phosphorylation site {S393} Ser phosphorylation site {S421} Ser phosphorylation site {S423} binding site FOR-BINDING-OF: retinoblastoma-associated protein histone deacetylase 2 COMPARTMENT: cell nucleus MOTIF: Histone deacetylase {9-322} MOTIF: histidine residue {H142} glycine-rich region {300-303} Ser phosphorylation site {S394} Ser phosphorylation site {S407} Ser phosphorylation site {S422} Ser phosphorylation site {S424} SAP30 protein inhibitor of growth protein 2 COMPARTMENT: cytoplasm cell nucleus MOTIF: coiled coil {48-120} Zn finger PHD-type NAME: Zn finger PHD-type SITE: 212-261 EFFECTOR-BOUND: Zn+2 MOTIF: binding site SITE: 214-214 FOR-BINDING-OF: Histone H3K4me3 binding site SITE: 225-225 FOR-BINDING-OF: Histone H3K4me3 binding site SITE: 229-229 FOR-BINDING-OF: Histone H3K4me3 binding site SITE: 237-237 FOR-BINDING-OF: Histone H3K4me3 PBR {264-280} histone-binding protein RBBP4 COMPARTMENT: cell nucleus MOTIF: acetylation site SITE: N-TERMINUS EFFECTOR-BOUND: acetyl WD repeat {122-155} WD repeat {175-206} WD repeat {225-256} WD repeat {271-302} WD repeat {315-346} WD repeat {372-403} histone-binding protein RBBP7 COMPARTMENT: cell nucleus MOTIF: WD repeat {121-152} WD repeat {174-205} WD repeat {224-255} WD repeat {270-301} WD repeat {314-345} Ser phosphorylation site {S354} WD repeat {371-402} Ser phosphorylation site {S413} Thr phosphorylation site {T416}

References

UniProt :accession Q9H160

Components

histone deacetylase 1 (reduced potassium dependency 3 [RPD3] homolog-like 1, HDAC1, RPD3L1) histone deacetylase 2 (HDAC2) histone-binding protein RBBP4; retinoblastoma-binding protein 4; RBBP-4; retinoblastoma-binding protein p48; chromatin assembly factor 1 subunit C; CAF-1 subunit C; chromatin assembly factor I p48 subunit; CAF-I 48 kD subunit; CAF-I p48; nucleosome-remodeling factor subunit RBAP48 (RBBP4, RbAp48) histone-binding protein RBBP7; retinoblastoma-binding protein 7; RBBP-7; retinoblastoma-binding protein p46; histone acetyltransferase type B subunit 2; nucleosome-remodeling factor subunit RBAP46 (RBBP7, RBAP46, HAT2) inhibitor of growth protein 2; inhibitor of growth 1-like protein; ING1Lp; p32; p33ING2 (ING2, ING1L) paired amphipathic helix protein sin3a; murine yeast transcription repressor Sin3 homolog; transcriptional corepressor Sin3a; histone deacetylase complex subunit Sin3a (SIN3A, mSin3A) sin3-associated peptide, 30kD (SAP30, histone deacetylase complex subunit SAP30, sin3 corepressor complex subunit SAP30)