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mRNA surveillance SURF complex
Function:
- mRNA surveillance
Structure:
- subunits: ERF1, ERF3 (ERF3A or ERF3B), EEF2, UPF1/RENT1, SMG1, SMG8 & SMG9
General
molecular complex
Properties
SUBUNITS: eukaryotic peptide chain release factor GTP-binding subunit ERF3A
MOTIF: GTP-binding site
SITE: 81-88
GTP-binding site
SITE: 158-162
GTP-binding site
SITE: 220-223
elongation factor 2
COMPARTMENT: cytoplasm
CELL: most cell types*
ORGANISM: eukaryote*
MOTIF: S/T phosphorylation site
binding site
FOR-BINDING-OF: G-alpha
P-loop
EFFECTOR-BOUND: guanosine triphosphate
regulator of nonsense transcripts 1
COMPARTMENT: cytoplasm
MOTIF: Sufficient for interaction with RENT2 {1-415}
MOTIF: proline-rich region
SITE: 47-80
MOTIF: proline residue (SEVERAL)
Zn finger C2H2-type
SITE: 131-159
EFFECTOR-BOUND: Zn+2
Zn finger C4-type
SITE: 183-213
EFFECTOR-BOUND: Zn+2
ATP-binding site
NAME: ATP-binding site
SITE: 503-510
serine-rich region {1042-1129}
MOTIF: serine residue (SEVERAL)
Q motif {1089-1090}
Ser phosphorylation site {S1089}
Q motif {1107-1108}
Ser phosphorylation site {S1107}
Ser phosphorylation site {S1127}
serine/threonine protein kinase SMG1
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: SMG8/SMG9 interaction {1-1977}
MOTIF: FAT domain
NAME: FAT domain
SITE: 1131-1866
MOTIF: Tyr phosphorylation site
binding site
FOR-BINDING-OF: Paxillin
HEAT repeat {1817-1852}
PI3K/PI4K {2150-2478}
Thr phosphorylation site {T3550}
Ser phosphorylation site {S3556}
Ser phosphorylation site {S3570}
Thr phosphorylation site {T3573}
Ser phosphorylation site {S3576}
Thr phosphorylation site {T3577}
FATC {3629-3661}
STATE: active state
References
UniProt :accession P15170
Components
eukaryotic elongation factor 2 (EF2, EEF2)
eukaryotic peptide chain release factor GTP-binding subunit ERF3A; eukaryotic peptide chain release factor subunit 3a; eRF3a; G1 to S phase transition protein 1 homolog; G1/S transition protein 1 homolog; GTP-binding protein GST1-HS (GSPT1, ERF3A)
regulator of nonsense transcripts 1 (nonsense mRNA reducing factor 1, NORF1, up-frameshift suppressor 1 homolog, hUpf1, RENT1, KIAA0221, UPF1)
serine/threonine protein kinase SMG1; SMG-1; hSMG-1; 61E3.4; lambda/iota protein kinase C-interacting protein; lambda-interacting protein (SMG1, ATX, KIAA0421, LIP)