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mRNA decay complex
Function:
- degradation of mRNAs
Structure:
- complex of DCP2, LSM1, LSM3, LSM4, EXOSC2, EXOSC4, EXOSC10, PARN, XRN1, CNOT6, RENT1, RENT2 & RENT3B
General
molecular complex
Properties
SUBUNITS: mRNA decapping enzyme 2
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: Nudix hydrolase {95-226}
MOTIF: Nudix box {129-150}
manganese [Mn]-binding site
SITE: 144-144
manganese [Mn]-binding site
SITE: 148-148
Ser phosphorylation site {S246}
Ser phosphorylation site {S247}
Ser phosphorylation site {S249}
Ser phosphorylation site {S276}
Ser phosphorylation site {S284}
Ser phosphorylation site {S347}
U6 snRNA-associated Sm-like protein LSm1
COMPARTMENT: cell nucleus
MOTIF: RNA-binding motif
FOR-BINDING-OF: ribonucleic acid
U6 snRNA-associated Sm-like protein LSm3
COMPARTMENT: cell nucleus
MOTIF: RNA-binding motif
FOR-BINDING-OF: ribonucleic acid
U6 snRNA-associated Sm-like protein LSm4
COMPARTMENT: cell nucleus
MOTIF: RNA-binding motif
FOR-BINDING-OF: ribonucleic acid
poly(A)-specific ribonuclease PARN
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: Ser phosphorylation site {S163}
R3H {178-245}
lysine residue {326}
Ser phosphorylation site {S557}
Ser phosphorylation site {S587}
Ser phosphorylation site {S619}
Ser phosphorylation site {S623}
Ser phosphorylation site {S628}
5'-3' exoribonuclease 1
COMPARTMENT: cytoplasm
MOTIF: active site
Ser phosphorylation site {S1173}
Ser phosphorylation site {S1176}
CCR4-NOT transcription complex subunit 6
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: leucine-rich repeat
SITE: 50-73
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 75-95
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 96-122
MOTIF: leucine residue (SEVERAL)
Mg+2-binding site
SITE: 240-240
regulator of nonsense transcripts 1
COMPARTMENT: cytoplasm
MOTIF: Sufficient for interaction with RENT2 {1-415}
MOTIF: proline-rich region
SITE: 47-80
MOTIF: proline residue (SEVERAL)
Zn finger C2H2-type
SITE: 131-159
EFFECTOR-BOUND: Zn+2
Zn finger C4-type
SITE: 183-213
EFFECTOR-BOUND: Zn+2
ATP-binding site
NAME: ATP-binding site
SITE: 503-510
serine-rich region {1042-1129}
MOTIF: serine residue (SEVERAL)
Q motif {1089-1090}
Ser phosphorylation site {S1089}
Q motif {1107-1108}
Ser phosphorylation site {S1107}
Ser phosphorylation site {S1127}
regulator of nonsense transcripts 2
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: lysine-rich region {6-136}
MOTIF: lysine residue (SEVERAL)
coiled coil {54-134}
binding site
SITE: 94-133
FOR-BINDING-OF: regulator of nonsense transcripts 1
MIF4G 1 {168-431}
coiled coil {487-559}
MIF4G 2 {569-758}
binding site
SITE: 711-928
FOR-BINDING-OF: regulator of nonsense transcripts 3A
regulator of nonsense transcripts 3B
binding site
SITE: 757-1272
FOR-BINDING-OF: eukaryotic initiation factor 4A1
eukaryotic translation initiation factor 1
MOTIF: MIF4G 3 {773-986}
binding site
SITE: 839-859
FOR-BINDING-OF: regulator of nonsense transcripts 3B
glutamate-rich region {1025-1094}
MOTIF: glutamate residue (SEVERAL)
binding site
SITE: 1084-1272
FOR-BINDING-OF: regulator of nonsense transcripts 1
regulator of nonsense transcripts 3B
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: binding site
SITE: 30-255
FOR-BINDING-OF: regulator of nonsense transcripts 2
MOTIF: binding site
SITE: 52-57
FOR-BINDING-OF: regulator of nonsense transcripts 2
binding site
SITE: 430-447
FOR-BINDING-OF: RNA-binding protein 8A
NMD
References
UniProt :accession Q8IU60
Components
5'-3' exoribonuclease 1; strand-exchange protein 1 homolog (XRN1, SEP1)
CCR4-NOT transcription complex subunit 6 (cytoplasmic deadenylase, carbon catabolite repressor protein 4 homolog, CCR4 carbon catabolite repression 4-like, CNOT6, CCR4, KIAA1194)
mRNA-decapping enzyme 2; hDpc; nucleoside diphosphate-linked moiety X motif 20; Nudix motif 20 (DCP2, NUDT20)
poly(A)-specific ribonuclease PARN; polyadenylate-specific ribonuclease, deadenylating nuclease; deadenylation nuclease (PARN, DAN)
regulator of nonsense transcripts 1 (nonsense mRNA reducing factor 1, NORF1, up-frameshift suppressor 1 homolog, hUpf1, RENT1, KIAA0221, UPF1)
regulator of nonsense transcripts 2 (nonsense mRNA reducing factor 2, up-frameshift suppressor 2 homolog, hUpf2, UPF2, KIAA1408, RENT2)
regulator of nonsense transcripts 3B (nonsense mRNA reducing factor 3B, up-frameshift suppressor homolog 3B, hUpf3B, hUpf3p-X, UPF3B, RENT3B, UPF3X)
U6 snRNA-associated Sm-like protein LSm1; cancer-associated Sm-like; small nuclear ribonuclear CaSm (LSM1, CASM)
U6 snRNA-associated Sm-like protein LSm3 (MDS017)
U6 snRNA-associated Sm-like protein LSm4 (Glycine-rich protein, GRP)