mRNA decapping complex

Function: - decapping of ARE-containing mRNAs Structure: - subunits: - DCP1A, DCP2, EDC3, EDC4 & probably DDX6 - mRNA decapping enzyme(s)

Properties

SUBUNITS: mRNA decapping enzyme 1A COMPARTMENT: cytoplasm cell nucleus MOTIF: Ser phosphorylation site {S142} Ser phosphorylation site {S180} Ser phosphorylation site {S315} Ser phosphorylation site {S319} Ser phosphorylation site {S334} Ser phosphorylation site {S353} Thr phosphorylation site {T401} Ser phosphorylation site {S522} Ser phosphorylation site {S523} Ser phosphorylation site {S525} Thr phosphorylation site {T531} mRNA decapping enzyme 2 COMPARTMENT: cytoplasm cell nucleus MOTIF: Nudix hydrolase {95-226} MOTIF: Nudix box {129-150} manganese [Mn]-binding site SITE: 144-144 manganese [Mn]-binding site SITE: 148-148 Ser phosphorylation site {S246} Ser phosphorylation site {S247} Ser phosphorylation site {S249} Ser phosphorylation site {S276} Ser phosphorylation site {S284} Ser phosphorylation site {S347} enhancer of mRNA-decapping protein 3 COMPARTMENT: cytoplasm MOTIF: Ser phosphorylation site {S131} YjeF N-terminal {308-467} enhancer of mRNA-decapping protein 4 COMPARTMENT: cytoplasm cell nucleus MOTIF: WD repeat {174-214} WD repeat {230-277} WD repeat {295-334} WD repeat {342-393} serine-rich region {602-676} MOTIF: serine residue (SEVERAL) Ser phosphorylation site {S729} Ser phosphorylation site {S741} Ser phosphorylation site {S844} Ser phosphorylation site {S875} Ser phosphorylation site {S879} Ser phosphorylation site {S887} nuclear localization {913-934} coiled coil {954-1025} Ser phosphorylation site {S1067} Thr phosphorylation site {T1072} DEAD box protein 6 COMPARTMENT: cytoplasm MOTIF: Thr phosphorylation site {T36} Q motif {96-124} helicase NAME: helicase SITE: 127-298 MOTIF: ATP-binding site NAME: ATP-binding site SITE: 140-147 DEAD/H box NAME: DEAD/H box SITE: 246-249 Helicase C-terminal {308-468} mRNA decapping enzyme MOTIF: active site

References

UniProt :accession Q9Y5B9

Components

DEAD box protein 6; ATP-dependent RNA helicase p54; RCK protooncogene protein (DDX6) enhancer of mRNA-decapping protein 3 (YjeF domain-containing protein 1, LSM16 homolog, EDC3, LSM16, YJDC, PP844) enhancer of mRNA-decapping protein 4 (human enhancer of decapping large subunit, Hedls, autoantigen Ge-1, autoantigen RCD-8, EDC4, HEDLS) mRNA decapping enzyme mRNA decapping enzyme B; transcription factor SMIF; Smad4-interacting transcriptional co-activator; transcription factor SMIF (DCP1A, SMIF) mRNA-decapping enzyme 2; hDpc; nucleoside diphosphate-linked moiety X motif 20; Nudix motif 20 (DCP2, NUDT20)