Mps one binder kinase activator-like 1A; MOB kinase activator 1B; Mob1 homolog 1A; Mob1A; Mob1B (MOB1B, MOB4A, MOBKL1A)

Function: - activator of LATS1/2 in the Hippo signaling pathway - stimulates the kinase activity of STK38L - phosphorylated by STK3/MST2 & STK4/MST1 & this - phosphorylation enhances its binding to LATS1 - binds STK38L - interacts with LATS1 & LATS2 Structure: belongs to the MOB1/phocein family Compartment: cytoplasm. nucleus Expression: - expressed in adrenal gland, bone marrow, brain, lung, placenta, prostate, salivary gland, skeletal muscle, testis, thymus, thyroid gland, uterus, colon with mucosa, fetal brain & fetal liver

General

Mps one binder kinase activator-like nuclear protein phosphoprotein

Properties

SIZE: entity length = 216 aa MW = 25 kD COMPARTMENT: cytoplasm cell nucleus MOTIF: acetylation site SITE: N-TERMINUS EFFECTOR-BOUND: acetyl Thr phosphorylation site {T12} Thr phosphorylation site {T35} Zn+2-binding site SITE: 79-79 Zn+2-binding site SITE: 84-84 Zn+2-binding site SITE: 161-161 Zn+2-binding site SITE: 166-166

Database Correlations

OMIM 609282 UniProt Q7L9L4 Pfam PF03637 Entrez Gene 92597 Kegg hsa:92597

References

UniProt :accession Q7L9L4