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zinc finger FYVE domain-containing protein 9; mothers against decapentaplegic homolog-interacting protein; Madh-interacting protein; smad anchor for receptor activation; receptor activation anchor; hSARA; Novel serine protease; NSP (ZFYVE9, MADHIP, SARA, SMADIP)
Function:
- SARA binds with SMAD2 & SMAD3 & TGF-beta receptor, interacting with MH2 domain of SMAD2 & SMAD3
- phosphorylation of SMAD2 by TGF-beta receptor induces dissociation from SARA & formation of SMAD2/SMAD4 complexes & nuclear translocation
- role in recruiting unphosphorylated forms of SMAD2/SMAD3 to the TGF-beta receptor by controlling their subcellular localization & by interacting & colocalizing with the TGF-beta receptor
Structure:
- FYVE domain mediates binding to phospholipids & targets SMADs to endosomes
Compartment: cytoplasm
Alternative splicing:
- named isoforms=3
- at least one isoform may be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay
Expression:
- ubiquitous
- in the brain found primarily in the cerebrovascular smooth muscle cells & reactive astrocytes
Interactions
molecular events
Related
TGF-beta signalling
General
zinc finger protein
Properties
SIZE: MW = 156 kD
entity length = 1425 aa
COMPARTMENT: cytoplasm
MOTIF: Zn finger Fyve-type
SITE: 699-758
EFFECTOR-BOUND: Zn+2
binding site
SITE: 767-823
FOR-BINDING-OF: SMAD protein
References
- UniProt :accession O95405
- Tsukazaki T et al
SARA, a FYVE domain protein that recruits Smad2 to the
TGFbeta receptor.
Cell 95:779-791, 1998
PMID: 9865696
Component-of
molecular complex
Databases & Figures
OMIM 603755
UniProt O95405
Pfam PF01363
Entrez Gene 9372
Kegg hsa:9372
TGF-beta/BMP signaling