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Mort1 FADD protein; FAS-associated death domain protein; FAS-associating death domain-containing protein; mediator of receptor induced toxicity; growth-inhibiting gene 3 protein (FADD, MORT1, GIG3)
Function:
- binds to the death domain of FAS/APO1 & induces apoptosis
- apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to activated Fas (CD95) or TNFR-1 receptors; resulting aggregate, death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation
- active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis
- interacts with CFLAR, PEA15 & MBD4
- when phosphorylated, part of a complex containing HIPK3 & FAS
- may interact with MAVS/IPS1
- interacts with MOCV v-CFLAR protein & LRDD
Structure:
- contains a death domain involved in the binding of the corresponding domain within Fas receptor
- contains 1 death domain
- contains 1 DED (death effector) domain
Expression:
- expressed in a wide variety of tissues
- not expressed in peripheral blood mononuclear leukocytes
Interactions
molecular events
Related
MORT1 homology domain
General
phosphoprotein
pro apoptotic protein
receptor
Properties
SIZE: entity length = 208 aa
MW = 23 kD
MOTIF: acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
death effector domain {3-81}
MOTIF: Ser phosphorylation site {S41}
death domain
NAME: death domain
SITE: 97-181
Ser phosphorylation site {S194}
Ser phosphorylation site {S197}
Database Correlations
OMIM 602457
UniProt Q13158
PFAM correlations
Entrez Gene 8772
KEGG correlations
References
- UniProt :accession Q13158
- NIEHS-SNPs
http://egp.gs.washington.edu/data/fadd/
- Chinnaiyan et al
Cell 81:505 1995
Component-of
molecular complex