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MORC family CW-type zinc finger protein 3; zinc finger CW-type coiled-coil domain protein 3 (MORC3, KIAA0136, ZCWCC3. NXP2)
Function:
- nuclear factor
- forms MORC3-nuclear bodies via an ATP-dependent mechanism
- sumoylated MORC3-nuclear bodies can also associate with PML-nuclear bodies
- recruits TP53 & SP100 to PML-nuclear bodies, thus regulating TP53 activity
- binds RNA in vitro [8]
- sumoylation is involved in interaction with PML & localization to PML nuclear bodies
- interacts with PML (via SUMO-interacting motif) [2,5]
- interacts with PT53 [2]
Structure:
- homodimer . the sumoylated form
- contains 1 CW-type zinc finger
Compartment: nucleus, nucleoplasm, nucleus matrix
Expression:
- expressed in heart, placenta, skeletal muscle, brain, pancreas, lung, liver
- not expressed in kidney
Pathology:
- may be required for influenza A transcription during viral infection
- interacts with influenza A virus PA & PB1 polymerase subunits during infection
- autoautibodies (Mj Ab) in polymyositis/dermatomyositis [9]
Laboratory:
- Mj Ab in serum
- Mj IgG in serum
General
phosphoprotein
zinc finger protein
Properties
SIZE: MW = 107 kD
entity length = 939 aa
MOTIF: Nuclear matrix binding {326-353}
Zinc finger
NAME: Zinc finger
SITE: 404-454
EFFECTOR-BOUND: Zn+2
RNA binding {500-591}
MOTIF: Ser phosphorylation site {S503}
Ser phosphorylation site {S514}
Ser phosphorylation site {S540}
Ser phosphorylation site {S560}
coiled coil {686-877}
MOTIF: Ser phosphorylation site {S765}
Database Correlations
OMIM 610078
UniProt Q14149
Pfam PF07496
Entrez Gene 23515
Kegg hsa:23515
References
- UniProt :accession Q14149
- PMID: 17332504
- PMID: 332504
- PMID: 26202233
- PMID: 20501696
- PMID: 501696
- PMID: 20501696
- PMID: 11927593
- Ceribelli A, Fredi M, Taraborelli M,
Anti-MJ/NXP-2 autoantibody specificity in a cohort of
adult Italian patients with polymyositis/dermatomyositis.
Arthritis Res Ther. 2012 Apr 30;14(2):R97.
PMID: 22546500 Free PMC Article