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monoclonal antibody SAR2365535
Indications:
- dyslipidemia, with increased LDL cholesterol
- may be used with statin
Mechanism of action:
- inhibits PCSK9
- decreases LDL cholesterol (50%)
Interactions
drug adverse effects of anti-hyperlipidemic agents
General
PCSK9 inhibitor (ALN-PCS)
pharmaceutical monoclonal antibody
References
- Roth EM et al
Atorvastatin with or without an Antibody to PCSK9 in Primary
Hypercholesterolemia.
N Engl J Med. Oct 31, 2012
PMID: 23113833
http://www.nejm.org/doi/full/10.1056/NEJMoa1201832
- McKenney JM et al
Safety and efficacy of a monoclonal antibody to proprotein
convertase subtilisin/kexin type 9 serine protease, SAR236553/
REGN727, in patients with primary hypercholesterolemia
receiving ongoing stable atorvastatin therapy.
J Am Coll Cardiol. 2012 Jun 19;59(25):2344-53
PMID: 22463922