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monobenzone (Benoquin)
Indications:
- topical treatment of vitiligo
Contraindications:
- freckling
- hyperpigmentation caused by photosensitization following use of certain perfumes
- melasma (chloasma) of pregnancy
- hyperpigmentation resulting from inflammation of the skin
- cafe-au-lait spots
- pigmented nevi
- malignant melanoma
- pigmentation resulting from pigments other than melanin (e.g.: bile, silver, or artificial pigments)
Dosage:
- applied topically BID-TID to permanently depigmented normal skin surrounding vitiliginous lesions in patients with disseminated (>50% of body surface area)
Cream: 20%
Adverse effects:
- allergic reaction, angioedema
- can can destruction of melanocytes & permanent depigmentation
Mechanism of action:
- increases excretion of melanin from melanocytes
General
ether
phenol
dermatologic agent
Database Correlations
PUBCHEM cid=7638
References
- Benoquin
http://www.drugs.com/pro/benoquin.html
- MedicineNet.com
http://www.medicinenet.com/monobenzone-topical/article.htm