Search
monoamine oxidase [MAO]-A
Function:
- catalyzes oxidative deamination of biogenic & xenobiotic amines
- role in metabolism of neuroactive & vasoactive amines in the central nervous system & peripheral tissues
- MAOA preferentially oxidizes biogenic amines including 5-hydroxytryptamine (5-HT), norepinephrine & epinephrine
RCH(2)NH(2) + H2O + O2 RCHO + NH3 + H2O2
Cofactor: FAD
Structure:
- monomer, homodimer or heterodimer (containing two subunits of similar size)
- each subunit contains a covalently bound flavin
- enzymatically active as monomer
- belongs to the flavin monoamine oxidase family
Compartment: mitochondria outer membrane, cytoplasmic side
Expression: heart, liver, duodenum, blood vessels & kidney
Pathology:
- defects in MAOA are the cause of Brunner syndrome
Laboratory:
- MAOA gene upstream VNTR repeats
General
monoamine oxidase (MAO)
Properties
SIZE: entity length = 527 aa
MW = 60 kD
COMPARTMENT: mitochondrial outer membrane (GO:0005741)
cytoplasm
MOTIF: acetylation site
SITE: 1-1
EFFECTOR-BOUND: acetyl
substrate specificity {335-335}
catalytic activity {374-374}
transmembrane domain {498-518}
Mitochondrial intermembrane {519-527}
Database Correlations
OMIM 309850
MORBIDMAP 309850
UniProt P21397
Pfam PF01593
Entrez Gene 4128
Kegg hsa:4128
ENZYME 1.4.3.4
References
- UniProt :accession P21397
- GeneReviews
https://www.genecards.org/cgi-bin/carddisp.pl?gene=MAOA
- Wikipedia; Note: monoamine oxidase entry
http://en.wikipedia.org/wiki/monoamine_oxidase