proteins expressed by microglia

Expression: 1) cytokines a) interleukins - IL-1 - IL-3 - IL-6 - IL-8 - IL-12 b) tumor necrosis factor (TNF)-alpha c) lymphotoxin d) transforming growth factor (TGF)-beta 2) chemokines a) macrophage inflammatory protein (MIP)-1 alpha b) MIP-1 beta c) RANTES d) monocyte chemotactic protein-1 (MCP-1) 3) eicosanoids - PGE2 4) complement components a) C1qB (C1q or C1q beta ?) b) C3 c) C4 5) matrix metalloproteinases a) matrixin-2 b) matrixin-9 6) reactive oxygen species - nitric oxide 7) others a) IL-1 receptor antagonist b) platelet-activating factor c) MHC class II - HLA B7-1 - HLA B7-2 d) ICAM-1 e) CD40

Specific

C-C motif chemokine 2; HC11; monocyte chemoattractant protein 1; monocyte chemotactic & activating factor; MCAF; monocyte chemotactic protein 1; MCP-1; monocyte secretory protein JE; small-inducible cytokine A2 (CCL2, MCP1, SCYA2) C-C motif chemokine 3; G0/G1 switch regulatory protein 19-1; macrophage inflammatory protein 1-alpha; MIP-1-alpha; PAT 464.1; SIS-alpha; small-inducible cytokine A3; tonsillar lymphocyte LD78 alpha protein; contains: MIP-1-alpha(4-69); LD78-alpha(4-69) (CCL3, G0S19-1, MIP1A, SCYA3) C-C motif chemokine 4; G-26 T-lymphocyte-secreted protein; HC21; lymphocyte activation gene 1 protein; LAG-1; MIP-1-beta(1-69); macrophage inflammatory protein 1-beta; MIP-1-beta; PAT 744; protein H400; SIS-gamma; small-inducible cytokine A4; T-cell activation protein 2; ACT-2; contains: MIP-1-beta(3-69) (CCL4, LAG1, MIP1B, SCYA4) CD40 [CDw40], TNF receptor family member 5 (TNFRSF5), Bp50 or B-cell activation protein CD40 complement C1q-beta chain (complement C1q subunit B, C1QB) complement-3 (C3) complement-4 (C4) HLA B7-1 HLA B7-2 intercellular adhesion molecule 1; ICAM-1; major group rhinovirus receptor; CD54 (ICAM1) interleukin-1 receptor antagonist protein; IL-1ra; IL-1RN; IRAP; IL1 inhibitor; ICIL-1RA (IL1RN, IL1F3, IL1RA) interleukin-12; cytotoxic lymphocyte maturation factor; NK cell stimulatory factor (IL12, IL-12) interleukin-1; lymphocyte-activating factor (IL1) interleukin-3; erythrocyte burst-promoting factor; hematopoietic growth factor; mast-cell colony-stimulating factor; multipotential colony-stimulating factor; colony-stimulating factor-2 alpha; mast cell growth factor; P-cell stimulating factor (IL3, IL-3) interleukin-6; IL-6; B-cell stimulatory factor 2; BSF-2; CTL differentiation factor; CDF; hybridoma growth factor; interferon beta-2; IFN-beta-2 (IL6, IFNB2) interleukin-8; IL-8; C-X-C motif chemokine 8; monocyte-derived neutrophil chemotactic factor; MDNCF; T-cell chemotactic factor; neutrophil-activating protein 1; NAP-1; protein 3-10C; Granulocyte chemotactic protein 1; GCP-1; monocyte-derived neutrophil-activating peptide; MONAP; emoctakin; lymphocyte-derived neutrophil-activating factor; LYNAP; neutrophil-activating factor; leukocyte adhesion inhibitor; NAF; MDNCF-c (IL8, CXCL8) lymphotoxin-alpha; LT-alpha; TNF-beta; tumor necrosis factor ligand superfamily member 1 (LTA, TNFB, TNFSF1) lymphotoxin-beta; LT-beta; tumor necrosis factor C; TNF-C; tumor necrosis factor ligand superfamily member 3 (LTB, TNFC, TNFSF3) matrix metalloproteinase-2 (matrixin-2, TBE-1, 72 kD gelatinase, gelatinase A, MMP2, CLG4A) matrix metalloproteinase-9 (matrixin-9, 92 kD gelatinase, gelatinase-B, MMP9, CLG4B) nitric oxide (NO, endothelium derived relaxation factor {EDRF}) platelet-activating factor (PAF) prostaglandin E2 (PGE2, dinoprostone, Prepidil, Cervidil) RANTES; C-C motif chemokine 5; EoCP; eosinophil chemotactic cytokine; SIS-delta; small-inducible cytokine A5; T cell-specific protein P228; TCP228; T cell-specific protein RANTES (CCL5, D17S136E, SCYA5) transforming growth factor [TGF]-beta tumor necrosis factor [TNF]-alpha; tumor necrosis factor ligand superfamily member 2; cachectin (TNF, TNFA, TNFSF2)

References

Benveniste et al, Neurochemistry International 39:381, 2001