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moesin; membrane-organizing extension spike protein (MSN)
Function:
- role in connections of major cytoskeletal structures to the plasma membrane
- associated with actin/integrin focal contacts
- phosphorylation on Thr-558 is crucial for the formation of microvilli-like structures (putative)
- in resting T-cells, part of a PAG1-SLC9A3R1-MSN complex which is disrupted upon TCR activation (putative)
- binds SLC9A3R1
Structure: contains 1 FERM domain
Compartment:
- cell membrane
- peripheral membrane protein cytoplasmic side (putative)
- cytoplasm, cytoskeleton
- apical cell membrane
- cell projection, microvillus membrane
- phosphorylated form is enriched in microvilli-like structures at apical membrane (putative)
Expression: expressed in all tissues & cultured cells studied
General
cytoskeletal protein
phosphoprotein
Properties
SIZE: entity length = 577 aa
MW = 68 kD
COMPARTMENT: cytoplasm
MOTIF: FERM domain
NAME: FERM domain
SITE: 2-295
MOTIF: Tyr phosphorylation site {Y116}
Thr phosphorylation site {T558}
Ser phosphorylation site {S576}
Database Correlations
OMIM 309845
UniProt P26038
PFAM correlations
Entrez Gene 4478
Kegg hsa:4478
References
- UniProt :accession P26038
- Atlas of Genetics & Cytogenetics in Oncology & Haematology
http://atlasgeneticsoncology.org/genes/MSNID363.html
- Stossel TP.
On the crawling of animal cells.
Science. 1993 May 21;260(5111):1086-94. Review.
PMID: 8493552