MLX-interacting protein (transcriptional activator mondoA, MLXIP KIAA0867 MIR)

Function: - binds DNA as a heterodimer with MLX & activates transcription - binds to the canonical E box sequence 5'-CACGTG-3' - role in transcriptional activation of glycolytic target genes - involved in glucose-responsive gene regulation - efficient DNA binding requires dimerization with another bHLH protein - binds DNA as a homodimer or a heterodimer with MLX Structure: contains 1 basic helix-loop-helix (bHLH) domain Compartment: - cytoplasm, nucleus, mitochondrial outer membrane - predominantly cytoplasmic, but shuttles between cytoplasm & nucleus when associated with MLX - associates with the outer mitochondrial membrane & may shuttle between the outer mitochondrial membrane & the nucleus Alternative splicing: named isoforms=5 Expression: - widely expressed in adult tissues - most abundant in skeletal muscle

General

helix loop helix transcription factor transcription factor (TF)

Properties

SIZE: entity length = 919 aa MW = 101 kD COMPARTMENT: cell nucleus MOTIF: cytoplasmic localization {73-327} transcriptional activation domain SITE: 322-445 DNA-binding motif SITE: 718-732 helix-loop-helix NAME: helix-loop-helix SITE: 754-768 FOR-BINDING-VIA: helix-loop-helix leucine zipper SITE: 769-790 FOR-BINDING-VIA: leucine zipper MLX interaction {832-881}

Database Correlations

OMIM 608090 UniProt Q9HAP2 Pfam PF00010

References

UniProt :accession Q9HAP2