MLL complex

Function: - histone methylation, possibly other chromosomal functions Structure: - subunits: - MLL, ASH2L, RBBP5, DPY30, WDR5, MEN1, HCFC1 & HCFC2 - facultative components include: - C17orf49, CHD8, E2F6, HSP70, IN80C, KIAA1267, LAS1L, MAX, MCRS1, MGA, KAT8/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 & TEX10

Properties

SUBUNITS: histone-lysine N-methyltransferase 2A COMPARTMENT: cell nucleus MOTIF: serine-rich region {17-102} MOTIF: serine residue (SEVERAL) glycine-rich region {137-143} Ser phosphorylation site {S153} A+T hook SITE: 169-180 Ser phosphorylation site {S197} A+T hook SITE: 217-227 A+T hook SITE: 301-309 Ser phosphorylation site {S518} proline-rich region SITE: 561-564 MOTIF: proline residue (SEVERAL) proline-rich region SITE: 568-571 MOTIF: proline residue (SEVERAL) Ser phosphorylation site {S680} Thr phosphorylation site {T840} Ser phosphorylation site {S926} Ser phosphorylation site {S1056} Zinc finger NAME: Zinc finger SITE: 1147-1195 EFFECTOR-BOUND: Zn+2 breakpoint {1334-1335} breakpoint {1362-1363} MOTIF: breakpoint {1362-1363} breakpoint {1362} breakpoint {1406-1407} Zn finger PHD-type NAME: Zn finger PHD-type SITE: 1431-1482 EFFECTOR-BOUND: Zn+2 MOTIF: breakpoint {1444-1445} breakpoint {1444-1445} Zn finger PHD-type NAME: Zn finger PHD-type SITE: 1479-1533 EFFECTOR-BOUND: Zn+2 Zn finger PHD-type NAME: Zn finger PHD-type SITE: 1566-1627 EFFECTOR-BOUND: Zn+2 Bromo; divergent {1703-1748} Thr phosphorylation site {T1845} Ser phosphorylation site {S1858} FYR N-terminal {2018-2074} Ser phosphorylation site {S2098} Thr phosphorylation site {T2147} Ser phosphorylation site {S2151} Ser phosphorylation site {S2201} Thr phosphorylation site {T2525} proteolytic site {2666-2667} proteolytic site {2718-2719} 9aaTAD {2847-2855} Ser phosphorylation site {S2955} Ser phosphorylation site {S3036} Thr phosphorylation site {T3372} Ser phosphorylation site {S3511} Ser phosphorylation site {S3515} FYR C-terminal {3666-3747} arginine residue {3765} SET domain {3829-3945} MOTIF: binding site SITE: 3839-3839 FOR-BINDING-OF: S-adenosylmethionine binding site SITE: 3841-3841 FOR-BINDING-OF: S-adenosylmethionine binding site SITE: 3883-3883 FOR-BINDING-OF: S-adenosylmethionine S-adenosyl-L-methionine binding {3906-3907} Zn+2-binding site SITE: 3909-3909 post-SET domain {3953-3969} MOTIF: Zn+2-binding site SITE: 3957-3957 binding site SITE: 3958-3958 FOR-BINDING-OF: S-adenosylmethionine Zn+2-binding site SITE: 3959-3959 Zn+2-binding site SITE: 3964-3964 Set1/Ash2 histone methyltransferase complex subunit ASH2 COMPARTMENT: cell nucleus MOTIF: Zn finger C4-type SITE: 117-150 EFFECTOR-BOUND: Zn+2 B30.2/SPRY {360-583} retinoblastoma binding protein 5 COMPARTMENT: cell nucleus MOTIF: WD repeat {22-63} WD repeat {64-103} WD repeat {148-188} MOTIF: Ser phosphorylation site {S182} Thr phosphorylation site {T193} WD repeat {196-235} WD repeat {249-291} MOTIF: Thr phosphorylation site {T252} WD repeat {293-331} Ser phosphorylation site {S350} Ser phosphorylation site {S388} Ser phosphorylation site {S389} Ser phosphorylation site {S497} Dpy-30-like protein COMPARTMENT: cell nucleus WD repeat-containing protein 5 COMPARTMENT: cell nucleus MOTIF: WD repeat {43-82} WD repeat {85-126} MOTIF: aspartate residue {107} WD repeat {128-168} MOTIF: phenylalanine residue {133} WD repeat {169-208} WD repeat {212-253} WD repeat {256-296} MOTIF: phenylalanine residue {263} Ser phosphorylation site {S267} WD repeat {299-333} MOTIF: glutamate residue {322} MEN1 host cell factor COMPARTMENT: cell nucleus MOTIF: kelch repeat {44-313} (5) binding site SITE: 610-722 FOR-BINDING-OF: paired amphipathic helix protein sin3a binding site SITE: 750-902 FOR-BINDING-OF: zinc finger & BTB domain-containing protein 17 binding site SITE: 813-912 FOR-BINDING-OF: GABP2 HCF {1010-1035} MOTIF: proteolytic site {1019-1020} HCF {1072-1097} MOTIF: proteolytic site {1081-1082} HCF {1101-1126} MOTIF: proteolytic site {1110-1111} HCF {1158-1183} HCF {1286-1311} MOTIF: proteolytic site {1295-1296} HCF {1314-1339} MOTIF: proteolytic site {1323-1324} HCF {1349-1374} HCF {1414-1439} MOTIF: proteolytic site {1423-1424} host cell factor 2 COMPARTMENT: cytoplasm cell nucleus MOTIF: kelch repeat {34-79} kelch repeat {83-130} kelch repeat {207-255} kelch repeat {257-303} fibronectin type III domain or F3 module {357-442} fibronectin type III domain or F3 module {580-672} fibronectin type III domain or F3 module {678-782}

Components

Dpy-30-like protein () histone-lysine N-methyltransferase 2A; lysine N-methyltransferase 2A; ALL-1; CXXC-type zinc finger protein 7; myeloid/lymphoid or mixed-lineage leukemia protein 1; trithorax-like protein; zinc finger protein HRX; contains: MLL cleavage product N320; N-terminal cleavage product of 320 kDa; p320; contains: MLL cleavage product C180; C-terminal cleavage product of 180 kD; p180 (KMT2A, ALL1, CXXC7, HRX, HTRX, MLL, MLL1) host cell factor 2 (HCF-2, C2 factor, HCFC2) host cell factor; HCF; HCF-1; C1 factor; VP16 accessory protein; VCAF; CFF (HCFC1, HCF1) retinoblastoma-binding protein 5; RBBP-5; retinoblastoma-binding protein RBQ-3 (RBBP5, RBQ3) Set1/Ash2 histone methyltransferase complex subunit ASH2 (ASH2-like protein, ASH2L) WD repeat-containing protein 5; BMP2-induced 3-kb gene protein (WDR5, BIG3)