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mllt10 gene
10p12
Pathology:
1) chromosomal translocation t(10;11)(p12;q23) involving MLLT10 with MLL/HRX is associated with acute leukemias
- result is a rogue activator protein
2) chromosomal translocation t(10;11)(p13;q14) involving MLLT10 with PICALM is associated with diffuse histiocytic lymphomas
Related
protein AF-10 (myeloid/lymphoid or mixed lineage leukemia translocated to 10, MLLT10, ALL1 fused gene from chromosome 10 protein, AF10)
General
unclassified gene
Properties
TEMPLATE-FOR: messenger RNA
TEMPLATE-FOR: protein AF-10
MOTIF: transcription factor binding site
transcriptional start site
exon
intron
transcriptional termination site
Database Correlations
OMIM 602409
Entrez Gene 8028
References
- OMIM :accession 602409
- Atlas of Genetics and Cytogenetics in Oncology and Haematology
http://atlasgeneticsoncology.org/Genes/AF10.html