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MLL3/MLL4 complex
Function:
1) coactivator complex of nuclear receptors
2) transcriptional coactivation
Structure:
- subunits include MLL3, MLL4, ASH2L, RBBP5, DPY30, WDR5, NCOA6, KDM6A, PAXIP1/PTIP & C16orf53/PA1
Notes:
- a related complex contains MLL2 instead of MLL4 (MLL2/MLL3 complex), thus putative Function: (obove)
General
molecular complex
Properties
SUBUNITS: histone-lysine N-methyltransferase MLL3
COMPARTMENT: cell nucleus
MOTIF: DNA-binding motif
SITE: 34-46
coiled coil {92-112}
Zinc finger
NAME: Zinc finger
SITE: 341-391
EFFECTOR-BOUND: Zn+2
MOTIF: RING-finger {344-389}
EFFECTOR-BOUND: Zn+2
FOR-BINDING-OF: DNA motif
Zinc finger
NAME: Zinc finger (3)
SITE: 388-520
EFFECTOR-BOUND: Zn+2
coiled coil {644-672}
Zinc finger
NAME: Zinc finger (3)
SITE: 957-1139
EFFECTOR-BOUND: Zn+2
coiled coil {1338-1366}
glutamine-rich region {1719-1796}
MOTIF: glutamine residue (SEVERAL)
coiled coil {1754-1787}
proline-rich region
SITE: 1834-2281
MOTIF: proline residue (SEVERAL)
proline-rich region
SITE: 2412-2630
MOTIF: proline residue (SEVERAL)
glutamine-rich region {3012-3509}
MOTIF: glutamine residue (SEVERAL)
coiled coil {3054-3081}
coiled coil {3173-3272}
proline-rich region
SITE: 3277-3381
MOTIF: proline residue (SEVERAL)
coiled coil {3391-3433}
SET domain {4770-4891}
post-SET domain {4895-4911}
histone-lysine N-methyltransferase 2B
COMPARTMENT: cell nucleus
MOTIF: acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
glycine-rich region {26-37}
A+T hook
SITE: 37-44
A+T hook
SITE: 110-117
proline-rich region
SITE: 248-255
MOTIF: proline residue (SEVERAL)
A+T hook
SITE: 357-365
acidic region {362-398}
MOTIF: acidic residue (SEVERAL)
proline-rich region
SITE: 402-771
MOTIF: proline residue (SEVERAL)
glutamine-rich region {808-812}
MOTIF: glutamine residue (SEVERAL)
Ser phosphorylation site {S821}
Ser phosphorylation site {S844}
Ser phosphorylation site {S861}
Zinc finger
NAME: Zinc finger
SITE: 959-1006
EFFECTOR-BOUND: Zn+2
Ser phosphorylation site {S1032}
Ser phosphorylation site {S1035}
Zn finger PHD-type
NAME: Zn finger PHD-type
SITE: 1201-1252
EFFECTOR-BOUND: Zn+2
Zn finger PHD-type
NAME: Zn finger PHD-type
SITE: 1249-1303
EFFECTOR-BOUND: Zn+2
Zn finger PHD-type
NAME: Zn finger PHD-type
SITE: 1335-1396
EFFECTOR-BOUND: Zn+2
FYR N-terminal {1727-1783}
Ser phosphorylation site {S1930}
proline-rich region
SITE: 1963-1970
MOTIF: proline residue (SEVERAL)
Thr phosphorylation site {T2068}
Ser phosphorylation site {S2070}
Thr phosphorylation site {T2083}
proline-rich region
SITE: 2251-2259
MOTIF: proline residue (SEVERAL)
FYR C-terminal {2411-2492}
SET domain {2575-2691}
MOTIF: binding site
SITE: 2585-2585
FOR-BINDING-OF: S-adenosylmethionine
binding site
SITE: 2587-2587
FOR-BINDING-OF: S-adenosylmethionine
binding site
SITE: 2629-2629
FOR-BINDING-OF: S-adenosylmethionine
binding site
SITE: 2652-2653
FOR-BINDING-OF: S-adenosylmethionine
Zn+2-binding site
SITE: 2655-2655
post-SET domain {2699-2715}
MOTIF: Zn+2-binding site
SITE: 2703-2703
binding site
SITE: 2704-2704
FOR-BINDING-OF: S-adenosylmethionine
Zn+2-binding site
SITE: 2705-2705
Zn+2-binding site
SITE: 2710-2710
Set1/Ash2 histone methyltransferase complex subunit ASH2
COMPARTMENT: cell nucleus
MOTIF: Zn finger C4-type
SITE: 117-150
EFFECTOR-BOUND: Zn+2
B30.2/SPRY {360-583}
retinoblastoma binding protein 5
COMPARTMENT: cell nucleus
MOTIF: WD repeat {22-63}
WD repeat {64-103}
WD repeat {148-188}
MOTIF: Ser phosphorylation site {S182}
Thr phosphorylation site {T193}
WD repeat {196-235}
WD repeat {249-291}
MOTIF: Thr phosphorylation site {T252}
WD repeat {293-331}
Ser phosphorylation site {S350}
Ser phosphorylation site {S388}
Ser phosphorylation site {S389}
Ser phosphorylation site {S497}
Dpy-30-like protein
COMPARTMENT: cell nucleus
WD repeat-containing protein 5
COMPARTMENT: cell nucleus
MOTIF: WD repeat {43-82}
WD repeat {85-126}
MOTIF: aspartate residue {107}
WD repeat {128-168}
MOTIF: phenylalanine residue {133}
WD repeat {169-208}
WD repeat {212-253}
WD repeat {256-296}
MOTIF: phenylalanine residue {263}
Ser phosphorylation site {S267}
WD repeat {299-333}
MOTIF: glutamate residue {322}
nuclear receptor coactivator 6
COMPARTMENT: cell nucleus
MOTIF: binding site
SITE: 1-1310
FOR-BINDING-OF: nuclear receptor coactivator 1
MOTIF: binding site
SITE: 1-1057
FOR-BINDING-OF: CREB-binding protein
binding site
SITE: 1-928
FOR-BINDING-OF: TBP/GTF2A
glutamine-rich region {227-1041}
MOTIF: glutamine residue (SEVERAL)
proline-rich region
SITE: 372-377
MOTIF: proline residue (SEVERAL)
binding site
SITE: 773-927
FOR-BINDING-OF: trimethylguanosine synthase
Ser phosphorylation site {S884}
LXXLL motif 1 {887-891}
lysine-rich region {913-918}
MOTIF: lysine residue (SEVERAL)
Thr phosphorylation site {T1321}
LXXLL motif 2 {1491-1495}
binding site
SITE: 1641-2063
FOR-BINDING-OF: EP300/CRSP3
KDM6
PAXIP
protein C16orf53
References
UniProt :accession Q8NEZ4
Components
Dpy-30-like protein ()
histone-lysine N-methyltransferase 2B; lysine N-methyltransferase 2B; myeloid/lymphoid or mixed-lineage leukemia protein 4; trithorax homolog 2; WW domain-binding protein 7; WBP-7 (KMT2B, HRX2, KIAA0304, MLL2, MLL4, TRX2, WBP7)
histone-lysine N-methyltransferase MLL3; homologous to ALR protein; lysine N-methyltransferase 2C; KMT2C; myeloid/lymphoid or mixed-lineage leukemia protein 3 (MLL3, HALR, KIAA1506, KMT2C)
nuclear receptor coactivator 6; amplified in breast cancer protein 3; cancer-amplified transcriptional coactivator ASC-2; activating signal cointegrator 2; ASC-2; peroxisome proliferator-activated receptor-interacting protein; PPAR-interacting protein; PRIP; nuclear receptor-activating protein, 250 kDa; nuclear receptor coactivator RAP250; NRC RAP250; thyroid hormone receptor-binding protein (NCOA6, AIB3, KIAA0181, RAP250, TRBP)
retinoblastoma-binding protein 5; RBBP-5; retinoblastoma-binding protein RBQ-3 (RBBP5, RBQ3)
Set1/Ash2 histone methyltransferase complex subunit ASH2 (ASH2-like protein, ASH2L)
WD repeat-containing protein 5; BMP2-induced 3-kb gene protein (WDR5, BIG3)