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MKL/myocardin-like protein 2 (myocardin-related transcription factor B, MRTF-B, megakaryoblastic leukemia 2, MKL2, KIAA1243, MRTFB)
Function:
- transcriptional coactivator of serum response factor (SRF)
- required for skeletal myogenic differentiation
- interacts with MKL1 & SRF
Structure:
- contains 3 RPEL repeats
- contains 1 SAP domain
- N-terminal region is required for nuclear localization
- C-terminal region mediates transcriptional activity
Compartment: nucleus
Alternative splicing: named isoforms=4
General
transcription factor (TF)
Properties
SIZE: MW = 118 kD
entity length = 1088 aa
COMPARTMENT: cell nucleus
MOTIF: RPEL {40-65}
Ser phosphorylation site {S66}
RPEL {84-109}
RPEL {128-153}
SAP {389-423}
coiled coil {545-601}
MOTIF: MKL1 interaction {563-591}
glutamine-rich region {671-787}
MOTIF: glutamine residue (SEVERAL)
Database Correlations
UniProt Q9ULH7
Pfam PF02037
References
UniProt :accession Q9ULH7