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mitogen-activated protein kinase kinase kinase MLK4; mixed lineage kinase 4 (MLK4, KIAA1804)
Function:
- activates the JUN N-terminal pathway
- autophosphorylation on Ser & Thr within the activation loop plays a role in enzyme activation
- homodimerization via the leucine zipper domains required for autophosphorylation & subsequent activation
Cofactor: Mg+2 (putative)
Structure:
- homodimer
- belongs to the protein kinase superfamily, STE Ser/Thr protein kinase family, MAP kinase kinase kinase subfamily
- contains 1 protein kinase domain
- contains 1 SH3 domain
Alternative splicing: named isoforms=3
General
mitogen-activated protein kinase kinase kinase (MAP3K) or MEK kinase (MEKK)
oligomerizing protein
Properties
SIZE: entity length = 1036 aa
MW = 114 kD
STATE: active state
MOTIF: serine-rich region {15-37}
MOTIF: serine residue (SEVERAL)
src homology 3 [SH3] domain
SITE: 38-102
Ser phosphorylation site {S114}
kinase domain
SITE: 124-401
MOTIF: ATP-binding site
NAME: ATP-binding site
SITE: 130-138
ATP-binding site
NAME: ATP-binding site
SITE: 151-151
aspartate residue {D263}
Thr phosphorylation site {T299}
Ser phosphorylation site {S303}
leucine zipper
SITE: 425-446
FOR-BINDING-VIA: leucine zipper
Ser phosphorylation site {S455}
leucine zipper
SITE: 460-481
FOR-BINDING-VIA: leucine zipper
Ser phosphorylation site {S514}
Ser phosphorylation site {S528}
Ser phosphorylation site {S543}
Ser phosphorylation site {S546}
Ser phosphorylation site {S547}
Thr phosphorylation site {T592}
Ser phosphorylation site {S614}
Ser phosphorylation site {S732}
Ser phosphorylation site {S773}
Ser phosphorylation site {S806}
Database Correlations
UniProt Q5TCX8
PFAM correlations
Entrez Gene 84451
Kegg hsa:84451
ENZYME 2.7.11.25
References
UniProt :accession Q5TCX8