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mitogen-activated protein kinase organizer 1; WD repeat domain-containing protein 83; MAPK organizer 1 (WDR83, MORG1)
Function:
1) molecular scaffold protein
- assembly of a multicomponent scaffold for the ERK pathway
2) enhances ERK activation at low levels, inhibits at high levels
3) response to hypoxia
a) negative regulation of HIF1A via EGLN3
b) degradation of HIF1A
4) may act by recruiting signaling complexes to a specific upstream activator
5) may also be involved in pre-mRNA splicing
6) interacts with EGLN3, MAP2K1, MAP2K2, MAP2K1IP1, ARAF, MAPK1, MAPK3
7) identified in the spliceosome C complex
Structure:
- belongs to the WD repeat MORG1 family
- contains 7 WD repeats
Compartment:
- cytoplasm, nucleus
- predominantly cytoplasmic, partially nuclear (putative)
General
scaffold protein
Properties
SIZE: entity length = 315 aa
MW = 34 kD
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: WD repeat {23-62}
WD repeat {65-104}
WD repeat {107-146}
WD repeat {151-188}
WD repeat {190-228}
WD repeat {231-272}
WD repeat {275-313}
Database Correlations
UniProt Q9BRX9
Pfam PF00400
Entrez Gene 84292
Kegg hsa:84292
References
UniProt :accession Q9BRX9
Component-of
spliceosome C complex