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mitogen-activated protein kinase kinase kinase 10 (MAP3K10, mixed lineage kinase [MLK] 2, MLK2, MST)
Function:
- activates the JUN N-terminal pathway (putative)
- homodimerization via the leucine zipper domains is required for autophosphorylation & subsequent activation
- autophosphorylation on serine & threonine residues within the activation loop plays a role in enzyme activation
ATP + a protein ADP + a phosphoprotein
Cofactor: Mg+2 (putative)
Structure:
- homodimer (putative)
- belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family, MAP kinase kinase kinase subfamily
- contains 1 protein kinase domain contains 1 SH3 domain
Expression: expressed in brain & skeletal muscle
General
mitogen-activated protein kinase kinase kinase (MAP3K) or MEK kinase (MEKK)
tyrosine kinase (protein tyrosine kinase, PTK)
Properties
SIZE: entity length = 954 aa
MW = 104 kD
STATE: active state
MOTIF: glutamate-rich region {2-5}
MOTIF: glutamate residue (SEVERAL)
src homology 3 [SH3] domain
SITE: 16-81
kinase domain
SITE: 98-360
MOTIF: ATP-binding site
NAME: ATP-binding site
SITE: 104-112
ATP-binding site
NAME: ATP-binding site
SITE: 125-125
aspartate residue {D222}
Thr phosphorylation site {T258}
Ser phosphorylation site {S262}
leucine zipper
SITE: 384-405
FOR-BINDING-VIA: leucine zipper
leucine zipper
SITE: 419-440
FOR-BINDING-VIA: leucine zipper
lysine-rich region {449-463}
MOTIF: lysine residue (SEVERAL)
Ser phosphorylation site {S506}
References
UniProt :accession Q02779
Databases & Figures
OMIM 600137
UniProt Q02779
PFAM correlations
Entrez Gene 4294
ENZYME 2.7.11.25
MAP kinase pathways