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transcription factor A, mitochondrial; mtTFA; mitochondrial transcription factor 1; MtTF1; transcription factor 6; TCF-6; transcription factor 6-like 2 (TFAM, TCF6, TCF6L2)
Function:
- role in mitochondrial transcription regulation
- required for accurate & efficient promoter recognition by the mitochondrial RNA polymerase
- activates transcription by binding immediately upstream of transcriptional start sites
- able to unwind & bend DNA
- interacts with TFB1M & TFB2M
Structure: contains 2 HMG box DNA-binding domains
Compartment: mitochondrial matrix
General
DNA-binding protein
mitochondrial protein
phosphoprotein
transcription factor (TF)
Properties
SIZE: entity length = 246 aa
MW = 29 kD
COMPARTMENT: mitochondria
MOTIF: HMG box
SITE: 50-118
HMG box
SITE: 155-219
MOTIF: Ser phosphorylation site {S193}
Database Correlations
OMIM 600438
UniProt Q00059
Pfam PF00505
Entrez Gene 7019
Kegg hsa:7019
References
- Parisi MA, Clayton DA.
Similarity of human mitochondrial transcription factor 1 to
high mobility group proteins.
Science. 1991 May 17;252(5008):965-9.
PMID: 2035027
- UniProt :accession Q00059