mitochondrial receptor complex; preprotein translocase complex; TOM complex

Function: - recognition & translocation of cytosolically synthesized mitochondrial preproteins across the mitochondrial outer membrane Structure: - consists of: - TOMM5 - TOMM6 - TOMM7 - TOMM20 (receptor) - TOMM22 (receptor) - TOMM34 (chaperon) - TOMM40 (translocation pore) - TOMM70

General

mitochondrial membrane protein molecular complex

Properties

COMPARTMENT: mitochondrial outer membrane (GO:0005741) MOTIF: membrane region SUBUNITS: mitochondrial import receptor subunit TOM5 homolog mitochondrial import receptor subunit TOM6 homolog COMPARTMENT: mitochondria MOTIF: Ser phosphorylation site {S63} mitochondrial import receptor subunit TOM7 homolog COMPARTMENT: mitochondria MOTIF: transmembrane domain {21-36} Mitochondrial intermembrane {37-55} mitochondrial import receptor subunit TOM20 homolog COMPARTMENT: mitochondrial outer membrane (GO:0005741) MOTIF: MITOCHONDRIAL INTERMEMBRANE {1-6} transmembrane domain {7-24} mitochondrial import receptor subunit TOM22 homolog COMPARTMENT: mitochondrial outer membrane (GO:0005741) MOTIF: acetylation site SITE: N-TERMINUS EFFECTOR-BOUND: acetyl Ser phosphorylation site {S15} Import sequence {41-50} MOTIF: Thr phosphorylation site {T43} TMD {83-103} MOTIF: transmembrane domain {84-103} Mitochondrial intermembrane {104-142} MOTIF: glutamine-rich region {110-118} MOTIF: glutamine residue (SEVERAL) C-tail signal {123-142} mitochondrial import receptor subunit TOM34 homolog COMPARTMENT: mitochondria cytoplasm MOTIF: tetratricopeptide repeat {9-42} tetratricopeptide repeat {51-84} tetratricopeptide repeat {86-118} membrane region Ser phosphorylation site {S186} tetratricopeptide repeat {193-226} tetratricopeptide repeat {227-260} tetratricopeptide repeat {262-294} mitochondrial import receptor subunit TOM40 homolog COMPARTMENT: mitochondria MOTIF: proline-rich region SITE: 10-39 MOTIF: proline residue (SEVERAL)

References

UniProt :accession Q15388

Components

mitochondrial import receptor subunit TOM20 homolog; mitochondrial 20 kD outer membrane protein; outer mitochondrial membrane receptor Tom20 (TOMM20, KIAA0016) mitochondrial import receptor subunit TOM22 homolog; translocase of outer membrane 22 kD subunit homolog (TOMM22, TOM22, hTom22, 1C9-2) mitochondrial import receptor subunit TOM34 homolog; translocase of outer membrane 34 kD subunit (TOMM34, URCC3) mitochondrial import receptor subunit TOM40 homolog; protein Haymaker; translocase of outer membrane 40 kD subunit homolog; p38.5 (TOMM40, C19orf1, PEREC1, TOM40) mitochondrial import receptor subunit TOM5 homolog (TOMM5, C9orf105, TOM5) mitochondrial import receptor subunit TOM6 homolog; overexpressed breast tumor protein; translocase of outer membrane 6 kD subunit homolog (TOMM6, OBTP, TOM6) mitochondrial import receptor subunit TOM7 homolog; translocase of outer membrane 7 kD subunit homolog (TOMM7, TOM7, TOMM07, AD-014)