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mitochondrial-processing peptidase
Function:
1) cleaves presequences (transit peptides) from mitochondrial protein precursors, typically with Arg in position P2
2) the beta subunit is catalytically active
Subunits:
- heterodimer of alpha & beta subunits
Compartment: mitochondrial matrix
General
mitochondrial membrane protein
molecular complex
zinc metalloprotease
Properties
COMPARTMENT: mitochondrial membrane
SUBUNITS: mitochondrial-processing peptidase subunit beta
MOTIF: Zn+2-binding site
SITE: 101-101
glutamate residue {E104}
Zn+2-binding site
SITE: 105-105
Zn+2-binding site
SITE: 181-181
cytochrome b-c1 complex subunit 1
MOTIF: Thr phosphorylation site {T381}
Database Correlations
ENZYME 3.4.99.41
References
- Martinus RD et al
Role of chaperones in the biogenesis and maintenance of the
mitochondrion.
FASEB J 9:371 1995
PMID: 7896006
Components
cytochrome b-c1 complex subunit 1, mitochondrial; complex III subunit 1; core protein I; ubiquinol-cytochrome-c reductase complex core protein 1; process-enhancing protein (UQCRC1)
mitochondrial-processing peptidase subunit beta (PMPCB)