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mitochondrial permeability transition pore complex (PTPC)
Function:
- voltage-dependent channel across:
a) inner mitochondrial membrane
b) outer mitochondrial membrane
- the open channel allows passage of molecules up to 15000 daltons, including
a) cytochrome C, a key mediator of apoptosis
b) adenine nucleotides (ATP, ADP) through the outer mitochondrial membrane
- both components (VDAC-1 & ANT) are voltage-gated.
- opening of ANT dissipates the H+ gradient across the inner mitochondrial membrane, uncoupling oxidative phosphorylation.
Structure:
- components include:
a) VDAC-1 (outer mitochondrial membrane)
b) ANT (inner mitochondrial membrane)
Related
ADP/ATP translocase, adenine nucleotide translocase (ANT) or ADP/ATP carrier protein
voltage-dependent anion-selective channel protein 1; VDAC-1; hVDAC1; outer mitochondrial membrane protein porin 1; plasmalemmal porin; porin 31HL; porin 31HM (VDAC1 VDAC)
General
biochemistry
References
- Adams JM, Cory S.
Life-or-death decisions by the Bcl-2 protein family.
Trends Biochem Sci. 2001 Jan;26(1):61-6. Review.
PMID: 11165519
- Sedlak TW, Snyder SH.
Messenger molecules and cell death: therapeutic implications.
JAMA. 2006 Jan 4;295(1):81-9.
PMID: 16391220