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mitochondrial carnitine/acylcarnitine carrier protein; carnitine/acylcarnitine translocase; CAC; solute carrier family 25 member 20 (SLC25A20, CAC, CACT)
Function:
- mediates transport of acylcarnitines of different length across the mitochondrial inner membrane from cytosol to mitochondrial matrix for their oxidation by the mitochondrial fatty acid-oxidation pathway
Structure:
- belongs to the mitochondrial carrier family
- contains 3 solcar repeats
Compartment:
- mitochondrial inner membrane
Pathology:
- defects in SLC25A20 are the cause of carnitine-acylcarnitine translocase deficiency
General
glycoprotein
mitochondrial protein
solute carrier family 20 (SLC20, SLC20A)
symporter
transmembrane 6 protein
Properties
SIZE: entity length = 301 aa
MW = 33 kD
COMPARTMENT: mitochondria
MOTIF: cytoplasmic domain {1-12}
transmembrane domain {13-31}
exoplasmic loop {32-73}
transmembrane domain {74-93}
cytoplasmic loop {94-112}
transmembrane domain {113-131}
mitochondrial matrix {132-170}
exoplasmic loop {132-170}
transmembrane domain {171-190}
cytoplasmic loop {191-211}
transmembrane domain {212-230}
mitochondrial matrix {231-267}
exoplasmic loop {231-267}
transmembrane domain {268-287}
cytoplasmic domain {288-301}
Database Correlations
OMIM 212138
UniProt O43772
Pfam PF00153
Kegg hsa:788
References
- UniProt :accession O43772
- GeneReviews
https://www.genecards.org/cgi-bin/carddisp.pl?gene=SLC25A20