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mitochondrial antibody in body fluid

Indications: - primary biliary cirrhosis* * primary biliary cirrhosis also known as primary biliary cholangitis * laboratory values indicating need for anti-mitochondrial antibody - elevated markers of cholangitis: increased serum ALP, serum GGT - normal to near normal serum AST, serum ALT, serum bilirubin Clinical significance: 1) autoantibody associated with primary biliary cirrhosis* directed at the mitochondrial M2 antigen 2) high titers (1:160) are diagnostic of primary biliary cirrhosis* a) antibodies preceed signs/symptoms b) occur in adults NOT children, with rare exceptions c) reacts with epitope in pyrvatate dehydrogenase-E2 containing lipoic acid 3) lower titers associated with a) chronic active hepatitis b) alcoholic hepatitis c) viral hepatitis * primary biliary cirrhosis also known as primary biliary cholangitis Specimen: - serum: store at -20 degrees C

Related

anti-mitochondrial antibody primary biliary cirrhosis; primary biliary cholangitis

Specific

mitochondrial antibody in CSF mitochondrial antibody in serum mitochondrial antibody qualitative mitochondrial antibody quantitative mitochondrial M2 antibody in body fluid

General

serology

References

  1. Medical Knowledge Self Assessment Program (MKSAP) 11, American College of Physicians, Philadelphia 1998
  2. Clinical Guide to Laboratory Tests, 3rd ed. Teitz ed., W.B. Saunders, 1995