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MIS12 complex
Function:
- required for normal chromosome alignment & segregation & kinetochore formation during mitosis
- required for spindle checkpoint activity
Structure:
- subunits: MIS12, DSN1, NSL1, ZWINT & PMF1
General
molecular complex
Properties
SUBUNITS: protein MIS12 homolog
COMPARTMENT: cell nucleus
MOTIF: coiled coil {108-205}
kinetochore-associated protein DSN1 homolog
COMPARTMENT: cell nucleus
MOTIF: Ser phosphorylation site {S28}
Ser phosphorylation site {S30}
Ser phosphorylation site {S86}
Kinetochore-associated protein NSL1 homolog
COMPARTMENT: cell nucleus
MOTIF: Ser phosphorylation site {S24}
Thr phosphorylation site {T242}
polyamine-modulated factor 1
COMPARTMENT: cell nucleus
MOTIF: coiled coil {141-193}
References
UniProt :accession Q9NZI8, Q9BZF9
Components
kinetochore-associated protein DSN1 homolog (DSN1, C20orf172)
Kinetochore-associated protein NSL1 homolog (NSL1 C1orf48 DC8 DC31)
polyamine-modulated factor 1 (PMF-1, PMF1)
protein MIS12 homolog (MIS12)