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dual specificity tyrosine-phosphorylation-regulated kinase 1B; minibrain-related kinase; Mirk protein kinase (DYRK1B, MIRK)
Function:
- dual-specificity kinase
- has both Ser/Thr kinase & tyrosine kinase activities
- enhances transcriptional activity of TCF1/HNF1A & FOXO1
- inhibits epithelial cell migration
- autophosphorylated on Tyr
- phosphorylated by MAP kinase
- Tyr phosphorylation may be required for dimerization
- interacts with DCOHM, MAP2K3/MKK3, RANBP9 & TCF1/HNF1A
- part of a complex consisting of RANBP9, RAN, DYRK1B & COPS5
- interacts with DCAF7
Inhibition:
- homodimer
- inhibited by RANBP9
Structure:
- belongs to the protein kinase superfamily, CMGC Ser/Thr protein kinase family, MNB/DYRK subfamily
- contains 1 protein kinase domain
Compartment: nucleus
Alternative splicing: named isoforms=3
Expression:
- highest expression in skeletal muscle, testis, heart & brain
- low expression in colon, lung
- expressed in a variety of tumor cell lines
Pathology:
- mediates colorectal carcinoma cell survival in mitogen-poor environments
General
dual-specificity tyrosine-phosphorylation regulated kinase
nuclear protein
Properties
SIZE: entity length = 629 aa
MW = 69 kD
COMPARTMENT: cell nucleus
MOTIF: nuclear translocation signal {69-86}
kinase domain
SITE: 111-431
MOTIF: ATP-binding site
NAME: ATP-binding site
SITE: 117-125
ATP-binding site
NAME: ATP-binding site
SITE: 140-140
aspartate residue {D239}
Tyr phosphorylation site {Y271}
Tyr phosphorylation site {Y273}
RANBP9 interaction {480-520}
proline-rich region
SITE: 558-561
MOTIF: proline residue (SEVERAL)
STATE: active state
Database Correlations
OMIM 604556
UniProt Q9Y463
Pfam PF00069
Entrez Gene 9149
Kegg hsa:9149
ENZYME 2.7.12.1
References
- UniProt :accession Q9Y463
- Atlas of Genetics & Cytogenetics in Oncology & Haematology
http://atlasgeneticsoncology.org/genes/DYRK1BID43235ch19q13.html