minor histocompatibility protein HMSD variant form; HSMD-v; contains: minor histocompatibility antigen ACC-6; mHA ACC-6 (HMSD)

Function: - allelic splice variant of HMSD - precursor of histocompatibility antigen ACC-6 - ACC-6 is presented to the cell surface by MHC HLA-B*4403 - this complex specifically elicits donor-cytotoxic T lymphocyte (CTL) reactivity against hematologic malignancies after treatment by HLA-identical allogenic BMT. - it induces cell recognition & lysis by CTL immunogenicity of most autosomal mHags results from single-nucleotide polymorphisms that cause amino-acid substitutions within epitopes, leading to the differential recognition of peptides between donor & recipient - ACC-6 forms a complex with MHC HLA-B*4403 Alternative splicing: named isoforms=2 - alternative splicing is due 1 intronic SNP Expression: - highly expressed in dendritic cells & primary leukemia cells, especially those of myeloid lineage. - ACC-6 expression is limited to cells of hematopoietic lineage Polymorphism: - minor histocompatibility antigen ACC-6 (mHA ACC-6) is encoded by HMSD-v which is an allelic variant of HMSD - HMSD-v results from an intronic single-nucleotide polymorphism located at position 5 of HMSD intron 2 leading to a G to A substitution - this variation in intron 2 induces skipping of exon 2 & frameshift, resulting in expression of ACC-6 Note: - translation of HMSD-v form generating mHA ACC-6 is in a frame different from that resulting in HMSD non variant form expression - thus, the HMSD non variant form sequence does not contain the mHA ACC-6 peptide

Properties

SIZE: entity length = 53 aa MW = 6 kD COMPARTMENT: plasma membrane MOTIF: membrane region

References

UniProt :accession P0C7T4