minor histocompatibility antigen

Function: - immunogenic peptide which, when complexed with MHC antigens, can generate an immune response after recognition by specific T-cells - the peptides are derived from polymorphic intracellular proteins, which are cleaved by normal pathways of antigen processing - the binding of these peptides to MHC class 1 or MHC class 2 molecules & expression on the cell surface can stimulate T-cell responses & thus trigger graft rejection or graft-versus-host disease after hematopoietic stem cell transplantation from an HLA-identical sibling donor

Related

major histocompatibility complex [MHC] antigen minor histocompatibility antigen (GO:0005558)

Specific

minor histocompatibility protein HA-1 ([contains: minor histocompatibility antigen HA-1 (mHag HA-1)], HMHA1 KIAA0223) Minor histocompatibility protein HB-1 ([contains: Minor histocompatibility antigen HB-1 (mHag HB-1)], HMHB1) minor histocompatibility protein HMSD variant form; HSMD-v; contains: minor histocompatibility antigen ACC-6; mHA ACC-6 (HMSD) myosin 1g [contains: minor histocompatibility antigen HA-2 (mHag HA-2)] (MYO1G)

General

antigen plasma membrane protein

Properties

COMPARTMENT: plasma membrane MOTIF: membrane region

References

UniProt :accession Q92619