Search
midkine; MK; amphiregulin-associated protein; ARAP; midgestation & kidney protein; neurite outgrowth-promoting factor 2; neurite outgrowth-promoting protein (MDK, MK1, NEGF2)
Function:
- developmentally regulated, secreted growth factor
- homologous to pleiotrophin (PTN), which has heparin binding activity
- binds anaplastic lymphoma kinase (ALK) which induces ALK activation & subsequent phosphorylation of IRS1, followed by activation of MAPK & PI3-kinase, & the induction of cell proliferation
- involved in neo-intima formation after arterial injury, possibly by mediating leukocyte recruitment
- also involved in early fetal adrenal gland development (putative)
- interacts with ALK
Structure:
- homodimer
- belongs to the pleiotrophin family
Compartment: secreted
Expression: induced by heparin & retinoic acid
General
growth factor
secreted protein
Properties
SIZE: entity length = 143 aa
MW = 16 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-20}
cysteine residue {C37}
MODIFICATION: cysteine residue {C61}
cysteine residue {C45}
MODIFICATION: cysteine residue {C70}
cysteine residue {C52}
MODIFICATION: cysteine residue {C74}
cysteine residue {C61}
MODIFICATION: cysteine residue {C37}
cysteine residue {C70}
MODIFICATION: cysteine residue {C45}
cysteine residue {C74}
MODIFICATION: cysteine residue {C52}
cysteine residue {C84}
MODIFICATION: cysteine residue {C116}
cysteine residue {C94}
MODIFICATION: cysteine residue {C126}
cysteine residue {C116}
MODIFICATION: cysteine residue {C84}
cysteine residue {C126}
MODIFICATION: cysteine residue {C94}
Database Correlations
OMIM 162096
UniProt P21741
PFAM correlations
Entrez Gene 4192
Kegg hsa:4192
References
UniProt :accession P21741