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microtubule-associated serine/threonine protein kinase 4 (MAST4, KIAA0303)
Function:
- presumptive serine/threonine protein kinase
- phosphorylated upon DNA damage, probably by ATM or ATR
Cofactor: Mg+2 (putative)
Structure:
- belongs to the protein kinase superfamily, AGC Ser/Thr protein kinase family
- contains 1 AGC-kinase C-terminal domain
- contains 1 PDZ domain (DHR domain)
- contains 1 protein kinase domain
Compartment: cytoplasm (putative)
Alternative splicing: named isoforms=5
Expression:
- highly expressed in most normal human tissues
- not highly expressed in testis, small intestine, colon or peripheral blood leukocytes
General
flavoprotein
glycoprotein
membrane protein
serine/threonine kinase
Properties
SIZE: entity length = 2626 aa
MW = 284 kD
COMPARTMENT: cytoplasm
MOTIF: Ser phosphorylation site {S114}
kinase domain
SITE: 573-846
MOTIF: ATP-binding site
NAME: ATP-binding site
SITE: 579-587
ATP-binding site
NAME: ATP-binding site
SITE: 602-602
aspartate residue {D696}
AGC-kinase C-terminal {847-919}
serine-rich region {1026-1140}
MOTIF: serine residue (SEVERAL)
PDZ domain
NAME: PDZ domain
SITE: 1144-1232
serine-rich region {1284-1346}
MOTIF: serine residue (SEVERAL)
Ser phosphorylation site {S1422}
Ser phosphorylation site {S1526}
Thr phosphorylation site {T1915}
Ser phosphorylation site {S1919}
proline-rich region
SITE: 2128-2211
MOTIF: proline residue (SEVERAL)
Ser phosphorylation site {S2555}
STATE: active state
Database Correlations
UniProt O15021
PFAM correlations
Entrez Gene 375449
Kegg hsa:375449
ENZYME 2.7.11.1
References
UniProt :accession O15021