microtubule-associated protein 9 (Aster-associated protein, MAP9, ASAP)

Function: - role in organization of the bipolar mitotic spindle - required for bipolar spindle assembly, mitosis progression & cytokinesis - may act by stabilizing interphase microtubules - binds to purified microtubules via its C-terminus - phosphorylated upon DNA damage, probably by ATM or ATR Compartment: - cytoplasm, cytoskeleton, spindle - localizes to microtubules in interphase - associates with mitotic spindle during mitosis - localizes to the central body during cytokinesis Alternative splicing: named isoforms=2 Expression: constitutively expressed during the cell cycle

General

microtubule-associated protein (MAP) phosphoprotein

Properties

SIZE: MW = 74 kD entity length = 647 aa COMPARTMENT: cytoplasm MOTIF: Ser phosphorylation site {S132} coiled coil {184-210} coiled coil {298-328} coiled coil {443-628}

References

UniProt :accession Q49MG5