microtubule-associated protein 4; MAP-4 (MAP4)

Function: - non-neuronal microtubule-associated protein - promotes microtubule assembly - phosphorylated upon DNA damage, probably by ATM or ATR - phosphorylation on Ser-787 negatively regulates MAP4 - activity to promote microtubule assembly - isoform 3 is phosphorylated on Ser-337 & Ser-338 Structure: contains 4 Tau/MAP repeats Alternative splicing: named isoforms=6 Expression: - non neuronal cells, although some neurons express MAP4

Properties

SIZE: entity length = 1152 aa MW = 121 kD COMPARTMENT: cytoplasm MOTIF: acetylation site SITE: N-TERMINUS EFFECTOR-BOUND: acetyl Ser phosphorylation site {S60} Ser phosphorylation site {S94} Thr phosphorylation site {T96} Thr phosphorylation site {T97} Ser phosphorylation site {S99} Ser phosphorylation site {S197} Ser phosphorylation site {S202} consensus repeat {248-545} (17) Thr phosphorylation site {T571} Ser phosphorylation site {S580} Thr phosphorylation site {T585} Ser phosphorylation site {S609} Ser phosphorylation site {S624} Thr phosphorylation site {T627} Ser phosphorylation site {S636} Ser phosphorylation site {S643} Ser phosphorylation site {S656} Ser phosphorylation site {S696} Ser phosphorylation site {S742} Ser phosphorylation site {S745} Ser phosphorylation site {S760} Ser phosphorylation site {S764} Ser phosphorylation site {S768} Ser phosphorylation site {S787} Ser phosphorylation site {S793} Thr phosphorylation site {T811} Ser phosphorylation site {S825} Ser phosphorylation site {S827} Thr phosphorylation site {T828} Thr phosphorylation site {T874} Ser phosphorylation site {S899} Ser phosphorylation site {S915} Thr phosphorylation site {T917} Tau/MAP {923-953} MOTIF: Thr phosphorylation site {T925} Ser phosphorylation site {S928} Ser phosphorylation site {S941} Tau/MAP {992-1022} MOTIF: Ser phosphorylation site {S1000} Tyr phosphorylation site {Y1001} Tau/MAP {1023-1053} MOTIF: Ser phosphorylation site {S1036} Ser phosphorylation site {S1037} Ser phosphorylation site {S1041} Tau/MAP {1054-1085} MOTIF: Ser phosphorylation site {S1073} Ser phosphorylation site {S1151}

Database Correlations

OMIM 157132 UniProt P27816 Pfam PF00418 Entrez Gene 4134 Kegg hsa:4134