microtubule-actin cross-linking factor 1, isoform 4 (macrophin 1, trabeculin-alpha, cross-linking factor 7, MACF1, ABP620, ACF7, KIAA0465, KIAA1251)

Function: 1) cross-linking cytoskeletal proteins 2) binds intermediate filaments to N-terminal plectin repeats & microtubules to C-terminus 3) contains 2 EF-hand domains - contains 19 plectin repeats - contains 32 spectrin repeats Compartment: cytoplasm Alternative splicing: named isoforms=5 Expression: - expressed in heart, lung, pituitary & placenta - not exressed in brain, kidney, liver, pancreas or skeletal muscle Notes: - entry removed from UniProt 5/9/12

Properties

SIZE: MW = 670 kD entity length = 5938 aa COMPARTMENT: cytoplasm MOTIF: Plectin {12-1196} (19) coiled coil {1830-1936} Spectrin {1925-5555} (32) coiled coil {5546-5569} EF hand SITE: 5585-5620 EF hand SITE: 5621-5656 MOTIF: Thr phosphorylation site {T5627}

Database Correlations

OMIM 608271 PFAM correlations

References

OMIM :accession 608271