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microtubule-actin cross-linking factor 1 (macrophin 1)
Function:
1) cross-linking cytoskeletal proteins
2) binds intermediate filaments to N-terminal plectin repeats & microtubules to C-terminus
Structure:
- contains EF-hand domains
- contains plectin repeats
- contains spectrin repeats
Compartment: cytoplasm
Alternative splicing: named isoforms=5
Expression:
- expressed in heart, lung, pituitary & placenta
- not exressed in brain, kidney, liver, pancreas or skeletal muscle
Specific
microtubule-actin cross-linking factor 1, isoform 4 (macrophin 1, trabeculin-alpha, cross-linking factor 7, MACF1, ABP620, ACF7, KIAA0465, KIAA1251)
microtubule-actin cross-linking factor 1, isoforms 1/2/3/5; actin cross-linking family protein 7; macrophin-1; trabeculin-alpha; 620 kD actin-binding protein; ABP620 (MACF1, ABP620, ACF7, KIAA0465, KIAA1251)
General
Ca+2 binding protein
cytoskeletal protein
phosphoprotein
Properties
SIZE: MW = 670 kD
entity length = 5938 aa
COMPARTMENT: cytoplasm
MOTIF: Plectin {12-1196} (19)
coiled coil {1830-1936}
Spectrin {1925-5555} (32)
coiled coil {5546-5569}
EF hand
SITE: 5585-5620
EF hand
SITE: 5621-5656
MOTIF: Thr phosphorylation site {T5627}
Database Correlations
OMIM 608271
UniProt Q9UPN3
PFAM correlations
Entrez Gene 23499
Kegg hsa:23499
References
UniProt :accession Q9UPN3