microspherule protein 1 (58 kD microspherule protein, cell cycle-regulated factor p78, MCRS2, MCRS1, MSP58)

Function: - modulates transcription repressor activity of DAXX by recruiting it to the nucleolus - may be an inhibitor of TERT telomerase activity - binds to NOL1, DAXX, PINX1, TERT & Herpes simplex virus ICP22 Structure: contains 1 FHA domain Compartment: - nucleus, nucleolus - in microspherules in the nucleolus Alternative splicing: named isoforms=3 Expression: - detected in testis > spleen, thymus, prostate, uterus, small intestine, colon, leukocytes - cell-cycle regulated: levels are highest early in S phase, not detectable in G2

General

nuclear protein phosphoprotein

Properties

SIZE: MW = 52 kD entity length = 462 aa COMPARTMENT: cell nucleus MOTIF: serine-rich region {11-102} MOTIF: serine residue (SEVERAL) Thr phosphorylation site {T103} Ser phosphorylation site {S108} nuclear translocation signal {113-123} Ser phosphorylation site {S282} coiled coil {301-335} forkhead-associated (FHA) domain {363-419}

Database Correlations

UniProt Q96EZ8 Pfam PF00498

References

UniProt :accession Q96EZ8