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microprocessor complex; pri-miRNA processing protein complex
Function:
- involved in the initial step of microRNA (miRNA) biogenesis
2) required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus
Structure:
- DGCR8 (heme-free or heme-bound forms)
- DROSHA
- may contain multiple subunits of DGCR8 & DROSHA
Compartment: nucleus
General
molecular complex
Properties
SUBUNITS: DiGeorge syndrome critical region 8
COMPARTMENT: cell nucleus
MOTIF: NCL interaction {1-342}
MOTIF: nuclear translocation signal {1-275}
Ser phosphorylation site {S92}
Ser phosphorylation site {S95}
Ser phosphorylation site {S109}
Ser phosphorylation site {S271}
Ser phosphorylation site {S275}
binding site
SITE: 276-751
FOR-BINDING-OF: heme-binding
MOTIF: WW domain (W/rsp5/WWP domain) {301-334}
Iron [Fe]-binding site
SITE: 352-352
Ser phosphorylation site {S377}
DROSHA interaction {484-773}
MOTIF: DRBM 1 {511-578}
DRBM 2 {620-685}
ribonuclease-3
COMPARTMENT: cell nucleus
MOTIF: proline-rich region
SITE: 1-212
MOTIF: proline residue (SEVERAL)
arginine-rich region {219-316}
MOTIF: arginine residue (SEVERAL)
RNase 3 {876-1056}
RNase 3 {1107-1233}
DRBM {1260-1334}
References
UniProt :accession Q8WYQ5
Components
DiGeorge syndrome critical region 8; microprocessor complex subunit DGCR8 (DGCR8, C22orf12, DGCRK6, LP4941)
ribonuclease 3 (Drosha, p241, RNase3, RNASEN, RN3, RNASE3L)