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HLA class II histocompatibility antigen gamma chain; HLA-DR antigens-associated invariant chain; Ia antigen-associated invariant chain; Ii; p33; CD74 (DHLAG)
Function:
- associates with MHC class II alpha & MHC class II beta chains in ER but dissociates in GOLGI after glycosylation
- some MHC class II gamma chain integrates into plasma membrane
- invariant MHC class II antigen
- role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis & directing transport of the complex from the endoplasmic reticulum to compartments where peptide loading of class II takes place
- nonamer composed of three alpha/beta/gamma heterotrimers
Structure: contains 1 thyroglobulin type-1 domain
Compartment: membrane
Alternative splicing: named isoforms=2
Expression:
- B cells
- activated T cells
- macrophages
- activated endothelial cells
- epithelial cells
General
cluster-of-differentiation antigen; cluster designation antigen; CD antigen
glycoprotein
protein subunit
Properties
SIZE: entity length = 296 aa
MW = 34 kD
COMPARTMENT: cellular membrane
MOTIF: Ser phosphorylation site {S25}
transmembrane domain {47-72}
CLIP {103-117}
N-glycosylation site {N130}
N-glycosylation site {N136}
Thyroglobulin type-1 {210-271}
MOTIF: cysteine residue {C213}
MODIFICATION: cysteine residue {C232}
cysteine residue {C232}
MODIFICATION: cysteine residue {C213}
cysteine residue {C243}
MODIFICATION: cysteine residue {C250}
cysteine residue {C250}
MODIFICATION: cysteine residue {C243}
cysteine residue {C252}
MODIFICATION: cysteine residue {C271}
cysteine residue {C271}
MODIFICATION: cysteine residue {C252}
Ser glycosylation site {S282}
Database Correlations
OMIM 142790
UniProt P04233
PFAM correlations
Entrez Gene 972
References
- MIM#142790
- http://www.pathologyoutlines.com/cdmarkers.html
20 January 2003
- Entrez Gene :accession 972
- UniProt :accession P04233